Figure 6b. Images in a 60-year-old woman with peau d’orange and a subareolar mass 3 cm in longest diameter. (a) Initial craniocaudal mammogram of the left breast shows skin thickening (arrowheads) and diffuse increased density. Biopsy of the skin disclosed inflammatory carcinoma. (b) Transverse US scans, obtained at the same time, depict a mass (arrow) 4 cm in longest diameter with irregular contour in the subareolar region. (c) Craniocaudal mammogram of the same breast 1 year after neoadjuvant chemotherapy shows that the pattern of edema regressed substantially, although there is still some skin thickening (arrowheads). No mass was depicted at US. Findings at histopathologic examination of the specimen removed at mastectomy showed that the invasive component of the tumor had totally resolved and had left behind only fibrosis and in situ foci.