Figure 3b. Primary tumor stage pT1pN1(7/13)G3 in the same 37-year-old patient as in Figure 2. (a) Coronal USPIO-enhanced MR images (left: T1-weighted SE 450/8; middle: fat-saturated T2-weighted fast SE 4,500/36; right: T1-weighted fast spoiled GRE 80/8 with a 40° flip angle) show two round nodes (arrows) with sizes of 2.1 x 1.6 cm (upper node) and 2.0 x 1.5 cm (lower node). The nodes are hypointense on T1-weighted SE images and hyperintense on T2-weighted fast SE images and show only thin peripheral USPIO enhancement. (b) Photomicrograph of a histologic sample of one lymph node metastasis. Arrowheads point to small rims of normal lymphatic tissue. The lymph node is otherwise replaced by metastatic tissue. (Hematoxylin-eosin stain; original magnification, x3.)