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Radiology, Vol 123, 505-509, Copyright © 1977 by Radiological Society of North America

ARTICLES

Thermal tolerance and repair of thermal damage by cultured cells

L Harisladis, DI Sung and EJ Hall

Exposure of hamster cells to 42.5 degrees C for long periods leads to the development of thermal tolerance; the slope of the survival curve become shallower after about 3.5 to 4 hours. If two 4-hour exposures at 42.5 degrees C are separated by various periods of time, thermal tolerance is eliminated by 20 hours. Prolonged exposure at 42.5 degrees C offers considerable protection from subsequent treatments to acute hyperthermia at 45 degrees C indicate or in conditioned medium or balanced salt solution failed to reveal any evidence of repair of potentially lethal damage.




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