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Radiology, Vol 125, 235-241, Copyright © 1977 by Radiological Society of North America

ARTICLES

Combined radiotherapy and Corynebacterium parvum treatment of a murine fibrosarcoma

AL Collins and CW Song

A single dose of Corynebacterium parvum (Cp) at 70 microgram, 175 microgram or 350 microgram was effective in suppressing the growth of a subcutaneous fibrosarcoma and occasionally in inducing complete regression and in prolonging the survival time of C3H/HeJ tumor-bearing mice. A single exposure of x rays at 2,000 rads induced some complete regression, but a higher number of complete regressions was induced by combined x-ray and Cp treatment. In the combined x-ray and Cp treatment, Cp given on the same day immediately after x irradiation was best. When 70 microgram of Cp was given a few days before x rays, the intravenous and intraperitoneal routes were better than the intratumor route of injection.




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