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Radiology, Vol 125, 525-527, Copyright © 1977 by Radiological Society of North America

ARTICLES

Potentiation of radiation effects in hypoxic HeLa cells

B Djordjevic and G Dymbort

HeLa cells were irradiated with two doses of gamma rays: the first dose was delivered under hypoxic conditions and the second dose was delivered under oxygenated conditions. Increased inactivation of cellular proliferative capacity as a function of intervening time was obtained when hypoxic conditions were maintained between doses. Hypoxic protection from ionizing irradiation can be counteracted by manipulating postirradiation conditions.




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Copyright © 1977 by the Radiological Society of North America.