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Radiology, Vol 126, 515-517, Copyright © 1978 by Radiological Society of North America

ARTICLES

Radionuclide imaging of metastases from renal-cell carcinoma by 131I- labeled antitumor antibody

P Belitsky, T Ghose, J Aquino, J Tai and AS MacDonald

On immunofluorescence assay, goat antisera reacted with renal-cell carcinomas from 20 patients, but not with adult normal human tissues (including patient's normal kidney). After in travenous injection, the 131I-labeled antibody localized preferentially in metastatic renal carcinoma in 6 consecutive patients. Labeled antitumor antibodies may have the specificity for tumor imagining which current radiopharmaceuticals lack.


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