Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greditzer, H. G.
Right arrow Articles by Beabout, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greditzer, H. G., 3d
Right arrow Articles by Beabout, J. W.

Radiology, Vol 146, 327-333, Copyright © 1983 by Radiological Society of North America

ARTICLES

Bone sarcomas in Paget disease

HG Greditzer 3d, RA McLeod, KK Unni and JW Beabout

The most serious complication of Paget disease is the development of sarcoma. Forty-one cases of bone sarcoma in Paget disease, which represented our institution's entire experience, were reviewed. The relative frequency of sarcomatous degeneration was 0.9%. Histologically, 35 of 41 lesions were osteogenic sarcomas, and six were fibrosarcomas. The distribution of lesions was similar to that expected with uncomplicated Paget disease, except for a disproportionately high number of lesions in the humerus; only one lesion involved the vertebrae. The tumors were categorized radiographically as lytic, mixed, and sclerotic, in descending order of frequency. The vast majority of lesions occurred in the pelvis, humerus, and femur. Overall prognosis for these patients was poor, with a five-year survival of 8%. Finding areas of cortical destruction is particularly useful in the detection of malignant degeneration. The radiologist must maintain a high index of suspicion when evaluating radiographs of patients with Paget disease, especially of those who present with pain or a palpable mass.


This article has been cited by other articles:


Home page
 ImagingHome page
P O'Donnell and P O'Donnell
Evaluation of focal bone lesions: basic principles and clinical scenarios
Imaging, December 1, 2003; 15(4): 298 - 323.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
S. E. Smith, M. D. Murphey, K. Motamedi, M. E. Mulligan, C. S. Resnik, and F. H. Gannon
From the Archives of the AFIP: Radiologic Spectrum of Paget Disease of Bone and Its Complications with Pathologic Correlation
RadioGraphics, September 1, 2002; 22(5): 1191 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
J. D. K. McNairn, T. A. Damron, S. K. Landas, J. L. Ambrose, and A. E. Shrimpton
Inheritance of Osteosarcoma and Paget's Disease of Bone: A Familial Loss of Heterozygosity Study
J. Mol. Diagn., November 1, 2001; 3(4): 171 - 177.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1983 by the Radiological Society of North America.