Radiology, Vol 151, 121-122, Copyright © 1984 by Radiological Society of North America
Comparison of iohexol with metrizamide in myelography
O Sortland, K Nestvold, R Kloster and MH Aandahl
Myelography of the lumbar and lower thoracic spine was performed in 46
patients (23 using metrizamide and 23 using iohexol) as a parallel double
blind randomized study. Neurological examinations, laboratory testing, and
EEG studies were performed before and after myelography, and side effects
were recorded. On comparison, adverse reactions were observed in a
statistically significant lower number of patients when iohexol was used.
The frequency and duration of each single adverse reaction was also lower
following use of iohexol, but this was not statistically significant. Three
patients had severe reactions following use of metrizamide, and in one
patient sharp waves were recorded on EEG. No severe reactions, no mental
reactions, and no muscular symptoms were seen following use of iohexol, and
we considered this contrast medium better tolerated in the subarachnoid
space than metrizamide.
