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Radiology, Vol 166, 761-765, Copyright © 1988 by Radiological Society of North America

ARTICLES

In-111-labeled liposomes: dosimetry and tumor depiction

AF Turner, CA Presant, RT Proffitt, LE Williams, DW Winsor and JL Werner
Department of Radiology, San Gabriel Medical Center, CA 91776.

Neutral phospholipid vesicles (liposomes) were loaded with 0.5 mCi (18.5 MBq) indium-111 and administered to 24 patients with various types of cancer. The median diameter of the liposomes was 77 nm, and lipid dose was 0.78-6.25 mg/kg. Scans obtained 24 and 48 hours after injection of In-111 liposomes showed gradual blood clearance with homogeneous uptake in the normal liver and spleen. Dosimetric estimates for these organs were 2.3 +/- 1.1 and 2.3 +/- 1.4 rad (.02 +/- .01 Gy), respectively, with a whole-body estimate of 0.28 rad (.003 Gy). Radiation dose did not correlate with lipid dose. Total renal excretion of In-111 was less than 2% of the injected dose in all but two patients. Transient eosinophilia occurred in two patients. Tumor was seen in the scans of 22 of 24 patients (unbinded readings). In-111- labeled liposomes may enable the demonstration of suspected or unsuspected sites of tumor.


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D. Emfietzoglou, K. Kostarelos, and G. Sgouros
An Analytic Dosimetry Study for the Use of Radionuclide-Liposome Conjugates in Internal Radiotherapy
J. Nucl. Med., March 1, 2001; 42(3): 499 - 504.
[Abstract] [Full Text]


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