Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carrasquillo, J. A.
Right arrow Articles by Schlom, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carrasquillo, J. A.
Right arrow Articles by Schlom, J.

Radiology, Vol 167, 35-40, Copyright © 1988 by Radiological Society of North America

ARTICLES

Peritoneal carcinomatosis: imaging with intraperitoneal injection of I- 131-labeled B72.3 monoclonal antibody

JA Carrasquillo, P Sugarbaker, D Colcher, JC Reynolds, J Esteban, G Bryant, P Perentesis, K Yokoyama, M Rotman and J Schlom
Department of Nuclear Medicine, National Cancer Institute, Bethesda, MD 20892.

Monoclonal antibody (MoAb) B72.3 is reactive with a variety of carcinomas such as colorectal and ovarian carcinoma and not reactive with a range of normal tissues in adults. Twelve patients, ranging in age from 16 to 63 years, with metastatic colorectal or appendiceal carcinoma were studied by means of radioimmunoscintigraphy after injection of 5-10 mCi (185-370 MBq) of iodine-131-labeled B72.3 immunoglobulin G (IgG). Eight of the 12 patients had positive scans. In three of these patients the MoAb scan depicted tumors that were not found by other means. Positive scans had excellent correlation with surgical findings in seven patients and caused underestimation of the extent of disease in one patient. In one patient the scan was technically inadequate and could not be evaluated. In three patients the scan was negative. No adverse reactions were associated with the infusions.


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
M. G. Rosenblum, C. F. Verschraegen, J. L. Murray, A. P. Kudelka, J. Gano, L. Cheung, and J. J. Kavanagh
Phase I Study of 90Y-labeled B72.3 Intraperitoneal Administration in Patients with Ovarian Cancer: Effect of Dose and EDTA Coadministration on Pharmacokinetics and Toxicity
Clin. Cancer Res., May 1, 1999; 5(5): 953 - 961.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1988 by the Radiological Society of North America.