Radiology, Vol 179, 123-132, Copyright © 1991 by Radiological Society of North America

ARTICLES

Chronic diffuse interstitial lung disease: diagnostic value of chest radiography and high-resolution CT

P Grenier, D Valeyre, P Cluzel, MW Brauner, S Lenoir and C Chastang
Department of Radiology, Hopital Jean Verdier, Bondy, France.

The diagnostic value of chest radiography and high-resolution computed tomography (CT) in chronic diffuse interstitial lung disease (CDILD) was assessed in 140 consecutive patients with diffuse infiltration of the lung visible at radiography. Radiographs and CT scans were separately read by three independent observers without knowledge of clinical and pathologic data. The observers listed the three most likely diagnoses and recorded the degree of confidence they had in their choice on a 0%-100% probability scale. Findings at radiography and high-resolution CT were recorded by each observer and were used for a stepwise discriminant analysis between diagnoses. First-choice diagnoses of all three observers that were made with a high level of confidence (probability, greater than or equal to 75%) were more accurate with CT than with radiography (P less than .001). The superiority of high-resolution CT over radiography was most obvious for histiocytosis X and sarcoidosis; in cases of pulmonary fibrosis, CT was not significantly different from radiography. The interobserver agreement for the proposed diagnosis was significantly better with high- resolution CT (P less than .001). Twenty-one of 26 radiographic findings and 21 of 25 CT findings were discriminant. Stepwise discriminant analysis revealed the superiority of CT over radiography, since the ranking of all findings showed that the four most discriminant findings, and eight of the first 12 findings, were revealed with CT.

This article has been cited by other articles:

				M. Thomeer, M. Demedts, J. Behr, R. Buhl, U. Costabel, C. D. R. Flower, J. Verschakelen, F. Laurent, A. G. Nicholson, E. K. Verbeken, et al. Multidisciplinary interobserver agreement in the diagnosis of idiopathic pulmonary fibrosis Eur. Respir. J., March 1, 2008; 31(3): 585 - 591. [Abstract] [Full Text] [PDF]

				C J Das, R Sharma, A Seith, and M P Baruah A young female with galactorrhoea and sudden onset chest pain Br. J. Radiol., August 1, 2006; 79(944): 703 - 705. [Full Text] [PDF]

				D. A. Lynch, W. D. Travis, N. L. Muller, J. R. Galvin, D. M. Hansell, P. A. Grenier, and T. E. King Jr Idiopathic Interstitial Pneumonias: CT Features Radiology, July 1, 2005; 236(1): 10 - 21. [Abstract] [Full Text] [PDF]

				U G Rossi and C M Owens The radiology of chronic lung disease in children Arch. Dis. Child., June 1, 2005; 90(6): 601 - 607. [Abstract] [Full Text] [PDF]

				Z. Amoura, P. Duhaut, D. L. T. Huong, B. Wechsler, N. Costedoat-Chalumeau, C. Frances, P. Cacoub, T. Papo, S. Cormont, Y. Touitou, et al. Tumor Antigen Markers for the Detection of Solid Cancers in Inflammatory Myopathies Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1279 - 1282. [Abstract] [Full Text] [PDF]

				P. De Vuyst, P. A. Gevenois, A. Van Muylem, and J. C. Yernault Changing Patterns in Asbestos-Induced Lung Disease Chest, September 1, 2004; 126(3): 999 - 999. [Full Text] [PDF]

				A. Fukushima, K. Ashizawa, T. Yamaguchi, N. Matsuyama, H. Hayashi, I. Kida, Y. Imafuku, A. Egawa, S. Kimura, K. Nagaoki, et al. Application of an Artificial Neural Network to High-Resolution CT: Usefulness in Differential Diagnosis of Diffuse Lung Disease Am. J. Roentgenol., August 1, 2004; 183(2): 297 - 305. [Abstract] [Full Text] [PDF]

				Z A Aziz, A U Wells, D M Hansell, G A Bain, S J Copley, S R Desai, S M Ellis, F V Gleeson, S Grubnic, A G Nicholson, et al. HRCT diagnosis of diffuse parenchymal lung disease: inter-observer variation Thorax, June 1, 2004; 59(6): 506 - 511. [Abstract] [Full Text] [PDF]

				G. F. Abbott, M. L. Rosado-de-Christenson, T. J. Franks, A. A. Frazier, and J. R. Galvin From the Archives of the AFIP: Pulmonary Langerhans Cell Histiocytosis RadioGraphics, May 1, 2004; 24(3): 821 - 841. [Abstract] [Full Text] [PDF]

				K. M. Sundar, M. V. Gosselin, H. L. Chung, and B. C. Cahill Pulmonary Langerhans Cell Histiocytosis: Emerging Concepts in Pathobiology, Radiology, and Clinical Evolution of Disease Chest, May 1, 2003; 123(5): 1673 - 1683. [Abstract] [Full Text] [PDF]

				M. Koyama, T. Johkoh, O. Honda, M. Tsubamoto, T. Kozuka, N. Tomiyama, S. Hamada, H. Nakamura, M. Akira, K. Ichikado, et al. Chronic Cystic Lung Disease: Diagnostic Accuracy of High-Resolution CT in 92 Patients Am. J. Roentgenol., March 1, 2003; 180(3): 827 - 835. [Abstract] [Full Text] [PDF]

				S. J. Copley, A. U. Wells, N. L. Muller, M. B. Rubens, N. P. Hollings, J. R. Cleverley, D. G. Milne, and D. M. Hansell Thin-Section CT in Obstructive Pulmonary Disease: Discriminatory Value Radiology, June 1, 2002; 223(3): 812 - 819. [Abstract] [Full Text] [PDF]

				M. Demedts and U. Costabel ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias Eur. Respir. J., May 1, 2002; 19(5): 794 - 796. [Full Text] [PDF]

				N.L. Muller Computed tomography and magnetic resonance imaging: past, present and future Eur. Respir. J., February 1, 2002; 19(35_suppl): 3S - 12s. [Abstract] [Full Text] [PDF]

				American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias . This Joint Statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS Board of Directors, June 2001 and by The ERS Executive Committee, June 2001 Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 277 - 304. [Full Text] [PDF]

				N.L. Muller Advances in imaging Eur. Respir. J., November 1, 2001; 18(5): 867 - 871. [Abstract] [Full Text] [PDF]

				E. A. Kazerooni High-Resolution CT of the Lungs Am. J. Roentgenol., September 1, 2001; 177(3): 501 - 519. [Full Text] [PDF]

				M. Demedts, A.U. Wells, J.M. Anto, U. Costabel, R. Hubbard, P. Cullinan, H. Slabbynck, G. Rizzato, V. Poletti, E.K. Verbeken, et al. Interstitial lung diseases: an epidemiological overview Eur. Respir. J., July 1, 2001; 18(32_suppl): 2S - 16s. [Abstract] [Full Text] [PDF]

				R.M. du Bois and A.U. Wells Cryptogenic fibrosing alveolitis/idiopathic pulmonary fibrosis Eur. Respir. J., July 1, 2001; 18(32_suppl): 43S - 55s. [Abstract] [Full Text] [PDF]

				M. Selman, T. E. King Jr., and A. Pardo Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy Ann Intern Med, January 16, 2001; 134(2): 136 - 151. [Abstract] [Full Text] [PDF]

				T. Johkoh, N. L. Müller, M. Akira, K. Ichikado, M. Suga, M. Ando, T. Yoshinaga, T. Kiyama, N. Mihara, O. Honda, et al. Eosinophilic Lung Diseases: Diagnostic Accuracy of Thin-Section CT in 111 Patients Radiology, September 1, 2000; 216(3): 773 - 780. [Abstract] [Full Text]

				P. SOLER, A. BERGERON, M. KAMBOUCHNER, O. GROUSSARD, M. BRAUNER, P. GRENIER, B. CRESTANI, H. MAL, A. TAZI, J. P. BATTESTI, et al. Is High-Resolution Computed Tomography a Reliable Tool to Predict the Histopathological Activity of Pulmonary Langerhans Cell Histiocytosis? Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 264 - 270. [Abstract] [Full Text]

				M. Abehsera, D. Valeyre, P. Grenier, H. Jaillet, J. P. Battesti, and M. W. Brauner Sarcoidosis with Pulmonary Fibrosis: CT Patterns and Correlation with Pulmonary Function Am. J. Roentgenol., June 1, 2000; 174(6): 1751 - 1757. [Abstract] [Full Text]

				T. King Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment . International Consensus Statement Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): 646 - 664. [Full Text]

				S. J. Copley, M. Coren, A. G. Nicholson, M. B. Rubens, A. Bush, and D. M. Hansell Diagnostic Accuracy of Thin-Section CT and Chest Radiography of Pediatric Interstitial Lung Disease Am. J. Roentgenol., February 1, 2000; 174(2): 549 - 554. [Abstract] [Full Text] [PDF]

				M. FARTOUKH, M. HUMBERT, F. CAPRON, S. MAÎTRE, F. PARENT, C. LE GALL, O. SITBON, P. HERVÉ, P. DUROUX, and G. SIMONNEAU Severe Pulmonary Hypertension in Histiocytosis X Am. J. Respir. Crit. Care Med., January 1, 2000; 161(1): 216 - 223. [Abstract] [Full Text]

				D. M Mitchell and A. Woodcock Introduction Thorax, August 1, 1999; 54(90002): S1 - 1. [PDF]

				T. Johkoh, N. L. Müller, Y. Cartier, P. V. Kavanagh, T. E. Hartman, M. Akira, K. Ichikado, M. Ando, and H. Nakamura Idiopathic Interstitial Pneumonias: Diagnostic Accuracy of Thin-Section CT in 129 Patients Radiology, May 1, 1999; 211(2): 555 - 560. [Abstract] [Full Text]

				A. Wells Clinical usefulness of high resolution computed tomography in cryptogenic fibrosing alveolitis Thorax, December 1, 1998; 53(12): 1080 - 1087. [Full Text]

				E. BOURGKARD, P. BERNADAC, N. CHAU, J.-P. BERTRAND, D. TECULESCU, and Q. T. PHAM Can the Evolution to Pneumoconiosis Be Suspected in Coal Miners? . A Longitudinal Study Am. J. Respir. Crit. Care Med., August 1, 1998; 158(2): 504 - 509. [Abstract] [Full Text] [PDF]

				B. W. Levine and V. Nickeleit Case 5-1994- A 34-Year-Old Woman with Mild Exertional Dyspnea and Interstitial Pulmonary Lesions N. Engl. J. Med., February 3, 1994; 330(5): 347 - 353. [Full Text]

				S. E. Weinberger Recent Advances in Pulmonary Medicine- First of Two Parts N. Engl. J. Med., May 13, 1993; 328(19): 1389 - 1397. [Full Text]

				B. T. SOCIETY and S. O. C. COMMITTEE The Diagnosis, Assessment and Treatment of Diffuse Parenchymal Lung Disease in Adults---British Thoracic Society recommendations Thorax, April 1, 1990; 54(90001): 1S - 28. [Full Text]