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Radiology, Vol 179, 681-686, Copyright © 1991 by Radiological Society of North America

ARTICLES

Dynamic gadolinium-enhanced MR imaging of the spleen: normal enhancement patterns and evaluation of splenic lesions

SA Mirowitz, JJ Brown, JK Lee and JP Heiken
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO.

The authors studied the ability to improve detection of splenic lesions during suspended respiration with dynamic gadolinium-enhanced T1- weighted spin-echo magnetic resonance (MR) imaging. In the first phase of the study, normal splenic contrast material enhancement patterns were assessed in 10 control patients without splenic lesions. A heterogeneous signal intensity pattern was observed in 11 patients with splenic lesions during bolus injection of gadopentetate dimeglumine, with conversion to homogeneous enhancement 1 minute later. Mean splenic enhancement was 321% during bolus injection, with a rapid return toward baseline signal intensity thereafter. In the second phase, evaluation of 18 splenic lesions detected with contrast-enhanced computed tomography in 11 patients revealed that dynamic gadolinium-enhanced MR pulse sequences significantly improved lesion conspicuity and detectability compared with conventional T1-and T2-weighted pulse sequences. Contrast-to-artifact ratio measurements were 0.5, 3.7, and 9.3 for conventional T1-weighted, T2-weighted, and dynamic gadolinium- enhanced MR images, respectively.


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K. M. Elsayes, V. R. Narra, G. Mukundan, J. S. Lewis Jr, C. O. Menias, and J. P. Heiken
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