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Radiology, Vol 181, 363-367, Copyright © 1991 by Radiological Society of North America

ARTICLES

Lobular carcinoma in situ: mammographic-pathologic correlation of results of needle-directed biopsy

MR Sonnenfeld, TH Frenna, N Weidner and JE Meyer
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

The mammographic and histologic findings were reviewed in 41 consecutive cases of isolated lobular carcinoma in situ (LCIS) unassociated with any malignant diagnosis. Thirty-one needle-directed breast biopsies were performed to evaluate clustered microcalcifications. In 24 of the 31 cases, the calcifications were found in areas of benign breast disease, with LCIS representing a separate process. In the few cases in which microcalcifications were seen in association with LCIS, a greater number of similar calcifications were present in adjacent benign disease. Soft-tissue abnormalities necessitating the performance of a biopsy represented benign foci, except in one patient with LCIS in and adjacent to a fibroadenoma. The authors conclude that LCIS has no characteristic mammographic features. LCIS is detected as an incidental finding at breast biopsy, with the mammographic abnormality predominantly reflecting a benign process.


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