Radiology, Vol 190, 553-559, Copyright © 1994 by Radiological Society of North America

ARTICLES

Improved contrast of enhancing brain lesions on postgadolinium, T1- weighted spin-echo images with use of magnetization transfer

DA Finelli, GC Hurst, RP Gullapali and EM Bellon
Department of Radiology, Metro-Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998.

PURPOSE: To prove that the contrast of enhancing brain lesions on post- gadolinium T1-weighted spin-echo (SE) images can be statistically significantly improved with magnetization-transfer (MT) indirect saturation. MATERIALS AND METHODS: The contrast-to-noise ratios (C/Ns) of 201 enhancing brain lesions in 110 patients were compared on conventional and MT T1-weighted SE images obtained at 1.5 T after injection of 0.05-0.10 mmol/kg gadopentetate dimeglumine or gadodiamide. RESULTS: The MT T1-weighted SE images showed a 37% reduction in signal intensity of background white matter and thereby provided a 108% improvement in the C/N of enhancing brain lesions over the conventional T1-weighted SE images (P < .001). CONCLUSION: The C/Ns obtained with single-dose gadolinium and the MT T1-weighted SE technique were twice those obtained with the conventional technique and are at least equivalent to reported values obtained with triple-dose gadolinium and conventional T1-weighted SE images.

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