Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Balazs, G.
Right arrow Articles by Herman, P. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Balazs, G.
Right arrow Articles by Herman, P. G.

Radiology, Vol 191, 269-272, Copyright © 1994 by Radiological Society of North America

ARTICLES

Bleomycin-induced fibrosis in pigs: evaluation with CT

G Balazs, S Noma, A Khan, T Eacobacci and PG Herman
Department of Radiology, Long Island Jewish Medical Center, Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, NY 11042.

PURPOSE: To establish an animal model for use in evaluation of early morphologic changes of pulmonary fibrosis by means of precise correlation of findings at thin-section computed tomography (CT) and pathologic findings. MATERIALS AND METHODS: Bleomycin (1.0-2.5 U per kilogram of body weight) was delivered selectively into the left lower lobe bronchus via balloon catheter in five Yorkshire pigs. Sequential CT examinations were performed at regular intervals. The animals were killed at follow-up of 5 days to 4 weeks. At autopsy, the lungs were removed, inflated, fixed and dried, and subsequently sliced into sections that corresponded to the CT sections. The fixed lungs were examined with thin-section CT, radiography, and histologic studies. RESULTS: There was good correlation between pathologic findings at CT and specimen radiography. Histologic study revealed signs of pneumonitis and developing fibrosis. CONCLUSIONS: This disease model is suitable for radiologic and pathologic evaluation of interstitial fibrosis. CT was sensitive in detection of bleomycin-induced abnormalities.


This article has been cited by other articles:


Home page
 Eur Respir JHome page
A. Bergeron, J-P. Laissy, P. Loiseau, E. Schouman-Claeys, A.J. Hance, and A. Tazi
Computed tomography of pulmonary sarcoid-like granulomas induced by complete Freund's adjuvant in rats
Eur. Respir. J., August 1, 2001; 18(2): 357 - 361.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1994 by the Radiological Society of North America.