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Radiology, Vol 192, 443-446, Copyright © 1994 by Radiological Society of North America

ARTICLES

Focal areas of increased opacity in ductal carcinoma in situ of the comedo type: mammographic-pathologic correlation

K Kinkel, R Gilles, C Feger, JM Guinebretiere, AA Tardivon, J Masselot and D Vanel
Department of Radiology, Institut Gustave Roussy, Villejuif, France.

PURPOSE: To determine a histopathologic explanation for focal areas of increased opacity on mammograms of ductal carcinoma in situ of the comedo type (comedocarcinoma). MATERIALS AND METHODS: From January 1991 to January 1993, mammograms from 36 patients with comedocarcinomas were reviewed. Each mammogram was screened for microcalcifications and/or any focal area of increased opacity. The presence or absence of infiltrating components was confirmed at pathologic examination, with particular emphasis placed on the search for any stromal reaction. RESULTS: The clinical examination revealed a palpable tumor in five patients (14%) and a bloody discharge from the nipple in two (5%). Isolated clusters of microcalcifications were seen at mammography in 24 patients (67%). Nine patients (25%) had clusters associated with focal areas of increased opacity; three patients (8%) had no microcalcifications. Histologic analysis demonstrated an intense, periductal, inflammatory reaction in all 12 patients with focal areas of increased opacity. CONCLUSION: Focal areas of increased opacity are not always indicative of an infiltrating component and may merely represent intense stromal reaction.


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S. Suryanarayanan, A. Karellas, S. Vedantham, I. Sechopoulos, and C. J. D'Orsi
Detection of Simulated Microcalcifications in a Phantom with Digital Mammography: Effect of Pixel Size
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