Radiology, Vol 194, 165-170, Copyright © 1995 by Radiological Society of North America
Circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil and doxorubicin: experimental study
T de Baere, J Dufaux, A Roche, JL Counnord, MF Berthault, A Denys and P Pappas
Department of Interventional Radiology, Institut Gustave Roussy, Villejuif, France.
PURPOSE: To evaluate circulatory alterations induced by intra-arterial
injection of iodized oil and emulsions of iodized oil with an anticancer
drug. MATERIALS AND METHODS: The viscosities and stability were evaluated
in arterial flow of iodized oil and the emulsions. Doppler ultrasound was
used to quantify the embolic effect in the arteries of rabbits. The
behavior of doxorubicin and iodized oil in the rat cremaster muscle was
studied with videomicroscopy. RESULTS: The emulsions did not break up after
injection, and the size of discontinuous-phase droplets did not change. The
embolic effect did not correlate with viscosity. The thinnest water-in-oil
emulsion had the lowest embolic effect and induced homogeneous distribution
of iodized oil droplets in the arterial tree. CONCLUSION: Changes in the
formulation of emulsions obtained with the same proportions of drug and
iodized oil change the distribution of iodized oil in the arterial tree,
the location at which the drug is released, and the embolic effect.
