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Radiology, Vol 196, 735-739, Copyright © 1995 by Radiological Society of North America

ARTICLES

Predictive value of MR imaging-dependent and non-MR imaging-dependent parameters for recurrence of laryngeal cancer after radiation therapy

JA Castelijns, MW van den Brekel, EM Smit, H Tobi, FW van Wagtendonk, RP Golding, HW Venema, C van Schaik and GB Snow
Department of Radiology, Free University Hospital, Amsterdam, The Netherlands.

PURPOSE: To determine the predictive value of several clinical and radiologic parameters for recurrence of laryngeal cancer. MATERIALS AND METHODS: Eighty previously untreated patients underwent magnetic resonance (MR) imaging before radiation therapy with curative intent. Tumor volume was calculated from T1-weighted MR images. Cartilage was considered invaded by pathologic tissue if it had intermediate signal intensity on T1-weighted spin-echo (SE) MR images and high signal intensity on T2-weighted SE MR images. The minimum follow-up was 2 years. RESULTS: Parameters such as age, sex, histopathologic findings, and invasion of the vocal muscle or pre-epiglottic space were not significantly correlated with tumor recurrence. Logistic regression analysis showed three relevant contributors: cord mobility, as judged clinically, and tumor volume and, more significantly, cartilage invasion, as seen at MR imaging. CONCLUSION: For untreated laryngeal cancer, MR imaging findings of tumor volume and cartilage invasion allow better patient selection for either radiation therapy or surgery. MR imaging is mandatory for T staging of laryngeal cancer.




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Copyright © 1995 by the Radiological Society of North America.