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Hepatocellular Carcinoma: MR Imaging Findings in Cirrhotic Livers and Noncirrhotic Livers

¹ Departments of Radiology (C.B.W., L.H.S., D.M.P.)
² Surgery (Y.F., L.H.B.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021.

PURPOSE: To compare the magnetic resonance (MR) imaging findings of primary hepatocellular carcinoma (HCC) in cirrhotic versus noncirrhotic livers.

MATERIALS AND METHODS: MR images in 36 patients with HCC (30 men and six women aged 42–84 years [mean age, 65 years]) were retrospectively reviewed. The number and size of hepatic lesions were assessed. Lesion margins were categorized as well circumscribed or ill defined. The presence of a capsule, intratumoral high signal intensity on T1-weighted MR images, and a stellate scar were determined.

RESULTS: Eleven (31%) patients had MR imaging evidence of cirrhosis, and 25 (69%) did not. Lesions in cirrhotic livers differed significantly from those in noncirrhotic livers in terms of size (22 cm² vs 99 cm², P < .05), frequency of a solitary lesion (27% vs 72%, P < .05), and frequency of a central scar (6% vs 50%, P < .05). There was no difference between the cirrhotic and noncirrhotic livers with regard to tumor margin, intratumoral high signal intensity on T1-weighted images, or tumor capsule.

CONCLUSION: Differences exist in the MR imaging appearance of HCC between patients with and those without cirrhosis, although there is overlap of imaging findings.

Index terms: Liver, cirrhosis, 761.794 • Liver, MR, 761.121411, 761.121412, 761.12143 • Liver neoplasms, 761.323

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