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Uveal Melanoma: Correlation of Histopathologic and Radiologic Findings by Using Thin-Section MR Imaging with a Surface Coil

¹ Universitätsklinikum Charité, Campus Virchow-Klinikum, Medizinische Fakultät der Humboldt Universität zu Berlin, Strahlenklinik und Poliklinik, Augustenburger Platz 1, D-13353 Berlin, Germany (A.J.L., N.H., M.R., C.S., R.F.)
² Universität-Gesamthochschule Essen, Augenklinik (N.B., A.S.)
³ Klinikum Benjamin-Franklin, Augenklinik und Poliklinik, (N.E.B.).

PURPOSE: To evaluate whether the different signal intensities at magnetic resonance (MR) imaging of melanoma are associated with a higher content of melanin.

MATERIALS AND METHODS: In a prospective study, MR imaging and ophthalmoscopic examination findings in 42 patients (19 women, 23 men; age range, 30–87 years) with uveal melanoma were compared with histopathologic examination findings obtained after enucleation. MR imaging was performed with 2-mm sections by using a 5-cm surface coil. T1- and T2-weighted images were obtained before and after contrast material administration.

RESULTS: In 33 (79%) of the patients, there was homogeneous tumor pigmentation, whereas in nine (21%) patients, there was inhomogeneous bipartite tumor pigmentation. Compared with the histopathologic data, the results of qualitative evaluation were accurate in 29 (58%) of 50 and in 26 (53%) of 49 tumorous areas on T1- and T2-weighted images, respectively. Quantitative evaluation yielded better results, especially at T1-weighted imaging; an 86% correlation was found. Because of methodological reasons, only the superficial pigmentation of inhomogeneous tumors could be evaluated with ophthalmoscopy.

CONCLUSION: Thin-section MR imaging of the eye enables an accurate prediction of melanomatous pigmentation with quantitative evaluation of plain T1-weighted images and is superior to ophthalmoscopy in cases of inhomogeneous pigmentation.

Index terms: Eye, MR, 224.12143, 224.12146 • Eye, neoplasms, 224.371 • Magnetic resonance (MR), surface coils, 224.12143, 224.12146 • Magnetic resonance (MR), tissue characterization, 224.12143, 224.12146 • Melanoma, 224.371

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