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Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with ^99mTc-DTPA Autoradiography in Rats¹

¹ From the Department of Radiology, Box 0628, University of California San Francisco Medical Center, 505 Parnassus Ave, Rm L308, San Francisco, CA 94143-0628. From the 1997 RSNA scientific assembly. Received Mar 26, 1998; revision requested May 5; revision received Aug 10; accepted Nov 5. Supported in part by National Institutes of Health grant no. R01 HL52569. H.A. supported by the Swedish Heart Lung Foundation (55501), the Swedish Medical Association (4.0), Hellmuth Herz Foundation, and the Swedish Royal Physiographic Society; J.B. supported by the ADUMED-foundation; and R.W. supported by the Swiss National Science Foundation as research fellows. Address reprint requests to C.B.H.

PURPOSE: To measure the fractional distribution volume of gadopentetate dimeglumine in normal and reperfused infarcted myocardium at magnetic resonance (MR) imaging by using the fractional distribution volume of technetium 99m–diethylenetriaminepentaacetic acid (DTPA) as an independent reference.

MATERIALS AND METHODS: Rats were subjected to 1 hour of coronary artery occlusion and 1 hour of reperfusion before inversion-recovery echo-planar imaging or autoradiography. Regional change in relaxation rate (R1) ratios for myocardium over blood were compared with radioactivity ratios for myocardium over blood after the injection of ^99mTc-DTPA.

RESULTS: Both R1 and radioactivity ratios demonstrated equilibrium distribution and hence represent partition coefficients (). The fractional distribution volumes were greater in infarcted myocardium (0.90 ± 0.05 for gadopentetate dimeglumine and 0.89 ± 0.04 for ^99mTc-DTPA) than in normal myocardium (0.23 ± 0.02 for gadopentetate dimeglumine and 0.16 ± 0.01 for ^99mTc-DTPA). Area at risk at autoradiography was not significantly different from that at histomorphometry. The infarction size defined by using triphenyltetrazolium chloride was 13% ± 4 smaller than that defined by using autoradiography.

CONCLUSION: The fractional distribution volumes of gadopentetate dimeglumine and ^99mTc-DTPA are similar and indicate extracellular distribution in normal myocardium and intracellular as well as extracellular distribution in reperfused infarction. Because the failure of cells to exclude these agents is indicative of necrosis, contrast medium–enhanced MR imaging may be useful to quantify myocardial infarction.

Index terms: Heart, experimental studies, 511.12143, 511.12172 • Magnetic resonance (MR), contrast enhancement, 511.121412, 511.121413, 511.12143 • Magnetic resonance (MR), echo planar, 511.121416 • Myocardium, infarction, 511.771 • Myocardium, ischemia, 511.1949 • Radionuclide imaging, experimental studies, 511.12143, 511.12172

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