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Cystic Fibrosis: Combined Hyperpolarized ³He-enhanced and Conventional Proton MR Imaging in the Lung-Preliminary Observations¹

¹ From the Departments of Radiology, Division of Pediatric Radiology (L.F.D., J.R.M., H.P.M., J.S., D.P.F., P.B., H.C.C., C.E.R.) and Pediatrics, Division of Pulmonary Medicine (J.M.M.), Duke University Medical Center, Durham, NC. From the 1998 RSNA scientific assembly. Received September 17, 1998; revision requested November 10; revision received November 19; accepted March 29, 1999. Address reprint requests to L.F.D., Department of Radiology, Children's Hospital Medical Center and the University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH 45229-3039.

Four patients with cystic fibrosis (CF) were examined with combined hyperpolarized helium 3–enhanced and conventional proton magnetic resonance (MR) imaging. After inhalation of the polarized ³He gas, single breath-hold, gradient-echo images (resonant frequency of ³He) were obtained to depict lung ventilation. Conventional T2-weighted fast spin-echo (hydrogen) images were also obtained to depict morphologic abnormalities. ³He images were successfully and reproducibly generated that showed both morphologic abnormalities and, often more extensive, ventilation abnormalities. ³He MR imaging may provide a method for evaluating progression of pulmonary disease in patients with CF.

Index terms: Fibrosis, cystic, 60.252 • Helium, 60.12147 • Lung, MR, 60.12143 • Magnetic resonance (MR), contrast enhancement, 60.12143 • Magnetic resonance (MR), nuclei other than H, 60.12147

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