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Experimental Studies |
1 From the Departments of Radiology (D.F.K., T.A.A., H.M.D.), Neurological Surgery (G.A.H., S.B.H.), and Pathology (J.W.M.), University of Virginia Health Services, Box 170, Charlottesville, VA 22908; and the Department of Radiology, Emory University, Atlanta, Ga (H.J.C.). Received September 22, 1998; revision requested November 20; revision received January 19, 1999; accepted April 30. T.A.A. supported in part by the RSNA Research and Education Foundation as a 1997 Research Resident. D.F.K. supported in part by the RSNA Research and Education Foundation as a 1997 Bracco/RSNA Scholar. Address reprint requests to D.F.K. (e-mail: dfk3b@virginia .edu).
PURPOSE: To characterize the histologic response to platinum coil embolization by using a rabbit aneurysm model.
MATERIALS AND METHODS: Saccular aneurysms were created in New Zealand White rabbits by using vessel ligation with intraluminal elastase incubation. Aneurysms were subsequently embolized by using platinum coils. Subjects were sacrificed at various intervals up to 12 weeks following coil embolization. The aneurysm cavities and adjacent vessels were embedded in methylmethacrylate, were sectioned, and were stained for histologic examination.
RESULTS: Two weeks following coil implantation, aneurysms were filled predominantly with unorganized thrombus. Six weeks following coil implantation, histologic features included complete filling of the aneurysm lumen with either prominent laminated but unorganized thrombus or areas of unorganized thrombus interspersed among areas of cellular infiltration. At 12 weeks following coil implantation, aneurysms were filled with the loosely packed, disordered cells contained within the extracellular matrix. Fibrosis or smooth muscle cell infiltration was not present in any of the 6- or 12-week samples.
CONCLUSION: Platinum coils placed into experimental saccular aneurysms in New Zealand White rabbits failed to elicit a fibrotic response. This model can be used for the testing of biologic modifications of platinum coils aimed at increasing intraaneurysmal fibrosis.
Index terms: Aneurysm, carotid, 172.73, 904.73 • Aneurysm, therapy, 172.1264, 904.1264, 904.73 • Carotid arteries, therapeutic blockade, 172.1264, 904.1264
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