| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Experimental Studies |
1 From the Departments of Radiology (H.J.C., T.A.A., W.F.M., R.J.R., M.E.J., J.E.D., D.F.K.), Neurosurgery (G.A.H., S.B.H.), and Pathology (J.W.M.), University of Virginia Health Sciences Center. Received April 13, 1998; revision requested July 1; final revision received December 16; accepted April 8, 1999. T.A.A. is supported by the RSNA Research and Education Foundation as a 1997 Research Resident. D.F.K. is supported by the RSNA Research and Education Foundation as a 1997 Bracco/RSNA Scholar. Address reprint requests to H.J.C., Department of Radiology, Emory University Hospital, 1364 Clifton Rd NE, Atlanta, GA 30322 (e-mail: harry_cloft@emory.org).
PURPOSE: To develop a rabbit model of an intracranial bifurcation aneurysm to test new endovascular therapies.
MATERIALS AND METHODS: An experimental aneurysm model was created in rabbits by means of endovascular balloon occlusion of the left common carotid artery, which created an aneurysm at the bifurcation formed by the aortic arch and the brachiocephalic trunk. A total of 18 aneurysms were created. In eight rabbits, the aneurysms were incubated with intraluminal elastase to induce degeneration of the elastic laminae. The animals were followed up with angiography for as long as 3 months. The animals were sacrificed at various times, and histologic evaluation of the aneurysm was performed.
RESULTS: Ten aneurysms created without elastase infusion were all very small or completely closed at 1–3 months. Six aneurysms created with elastase infusion had long-term patency (two were patent at 1 month and four, at 3 months). The elastase aneurysms had a mean width of 3 mm (range, 2–3.5 mm) and a mean length of 5 mm (range, 3–7 mm). Histologic evaluation revealed destruction of the normal elastin layers, which allowed the artery to become aneurysmal.
CONCLUSION: This aneurysm model re-created the hemodynamic forces and size of human cerebral bifurcation aneurysms and maintained the integrity of the endothelium. The creation of the aneurysms was rapid, reliable, and reproducible.
Index terms: Aneurysm, carotid, 904.73 • Aneurysm, cerebral, 17.73 • Aneurysm, therapy, 17.1264, 904.1264, 904.73 • Animals • Carotid arteries, therapeutic blockade, 17.1264, 904.1264
This article has been cited by other articles:
|
|
 |
|
  L. Gao, Y. Hoi, D. D. Swartz, J. Kolega, A. Siddiqui, and H. Meng Nascent Aneurysm Formation at the Basilar Terminus Induced by Hemodynamics Stroke, July 1, 2008; 39(7): 2085 - 2090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Meng, Z. Wang, Y. Hoi, L. Gao, E. Metaxa, D. D. Swartz, and J. Kolega Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation Stroke, June 1, 2007; 38(6): 1924 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.H. Ding, D. Dai, M.A. Danielson, R. Kadirvel, D.A. Lewis, H.J. Cloft, and D.F. Kallmes Control of Aneurysm Volume by Adjusting the Position of Ligation During Creation of Elastase-Induced Aneurysms: A Prospective Study AJNR Am. J. Neuroradiol., May 1, 2007; 28(5): 857 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dai, Y. H. Ding, M. A. Danielson, R. Kadirvel, L. W. Hunter, W.-Z. Zhan, G. A. Helm, D. A. Lewis, H. J. Cloft, G. C. Sieck, et al. Endovascular Treatment of Experimental Aneurysms by Use of Fibroblast-Coated Platinum Coils: An Angiographic and Histopathologic Study Stroke, January 1, 2007; 38(1): 170 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Meng, Z. Wang, M. Kim, R.D. Ecker, and L.N. Hopkins Saccular aneurysms on straight and curved vessels are subject to different hemodynamics: implications of intravascular stenting. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1861 - 1865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.H. Ding, D. Dai, D.A. Lewis, M.A. Danielson, R. Kadirvel, J.N. Mandrekar, H.J. Cloft, and D.F. Kallmes Can neck size in elastase-induced aneurysms be controlled? A retrospective study. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1681 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Onizuka, L. Miskolczi, M.J. Gounis, J. Seong, B.B. Lieber, and A.K. Wakhloo Elastase-induced aneurysms in rabbits: effect of postconstruction geometry on final size. AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1129 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.H. Ding, D. Dai, D.A. Lewis, M.A. Danielson, R. Kadirvel, H.J. Cloft, and D.F. Kallmes Long-Term Patency of Elastase-Induced Aneurysm Model in Rabbits AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 139 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. H. Ding, D. Dai, D. A. Lewis, M. A. Danielson, R. Kadirvel, J. N. Mandrekar, H. J. Cloft, and D. F. Kallmes Can Neck Size in Elastase-Induced Aneurysms Be Controlled? A Prospective Study AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2364 - 2367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Miskolczi, B. Nemes, L. Cesar, O. Masanari, and M. J. Gounis Contrast Injection via the Central Artery of the Left Ear in Rabbits: A New Technique to Simplify Follow-Up Studies AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1964 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Shin, Y. Niimi, Y. Yoshino, J. K. Song, M. Silane, and A. Berenstein Creation of Four Experimental Aneurysms with Different Hemodynamics in One Dog AJNR Am. J. Neuroradiol., August 1, 2005; 26(7): 1764 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Raymond, I. Salazkin, A. Metcalfe, O. Robledo, G. Gevry, D. Roy, A. Weill, and F. Guilbert Lingual Artery Bifurcation Aneurysms for Training and Evaluation of Neurovascular Devices AJNR Am. J. Neuroradiol., September 1, 2004; 25(8): 1387 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Fujiwara and D. F. Kallmes Healing Response in Elastase-Induced Rabbit Aneurysms after Embolization with a New Platinum Coil System AJNR Am. J. Neuroradiol., August 1, 2002; 23(7): 1137 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Kallmes, N. H. Fujiwara, S. S. Berr, G. A. Helm, and H. J. Cloft Elastase-Induced Saccular Aneurysms in Rabbits: A Dose-Escalation Study AJNR Am. J. Neuroradiol., February 1, 2002; 23(2): 295 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Short, N. H. Fujiwara, W. F. Marx, G. A. Helm, H. J. Cloft, and D. F. Kallmes Elastase-Induced Saccular Aneurysms in Rabbits: Comparison of Geometric Features with Those of Human Aneurysms AJNR Am. J. Neuroradiol., November 1, 2001; 22(10): 1833 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Fujiwara, H. J. Cloft, W. F. Marx, J. G. Short, M. E. Jensen, and D. F. Kallmes Serial Angiography in an Elastase-induced Aneurysm Model in Rabbits: Evidence for Progressive Aneurysm Enlargement after Creation AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 698 - 703. [Abstract] [Full Text]
|
|
|
|
|
|
W. F. Marx, H. J. Cloft, G. A. Helm, J. G. Short, H. M. Do, M. E. Jensen, and D. F. Kallmes Endovascular Treatment of Experimental Aneurysms by Use of Biologically Modified Embolic Devices: Coil-mediated Intraaneurysmal Delivery of Fibroblast Tissue Allografts AJNR Am. J. Neuroradiol., February 1, 2001; 22(2): 323 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Abruzzo, H. J. Cloft, and G. G. Shengelaia Reply AJNR Am. J. Neuroradiol., October 1, 2000; 21(9): 1771 - 1773. [Full Text]
|
|
|
|
 |
|
 T. A. Altes, H. J. Cloft, J. G. Short, A. DeGast, H. M. Do, G. A. Helm, and D. F. Kallmes Creation of Saccular Aneurysms in the Rabbit: A Model Suitable for Testing Endovascular Devices Am. J. Roentgenol., February 1, 2000; 174(2): 349 - 354. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
