| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Breast Imaging |
1 From the Departments of Radiology (K.H., O.P., D.N.S., P.E.H., N.J.M., J.K., F.A.J.) and Surgery (S.S.), Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115; and the Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Mass (J.B.). Received April 4, 2000; revision requested May 25; revision received June 23; accepted August 1. Supported in part by NCI program grant 67165, research grant CA 46627, contract 282-97-0080 from the U.S. PHS Office on Women’s Health, and a grant from GE Medical Systems. P.E.H. supported by German Research Council (DFG) grant HU 798/1-1. J.K. supported by the Austrian Science Foundation and the Research and Education Fund of the European Congress of Radiology. Address correspondence to K.H. (e-mail: kullervo@bwh.harvard.edu).
PURPOSE: To test the feasibility of noninvasive magnetic resonance (MR) imaging–guided focused ultrasound surgery (FUS) of benign fibroadenomas in the breast.
MATERIALS AND METHODS: Eleven fibroadenomas in nine patients under local anesthesia were treated with MR imaging-guided FUS. Based on a T2-weighted definition of target volumes, sequential sonications were delivered to treat the entire target. Temperature-sensitive phase-difference–based MR imaging was performed during each sonication to monitor focus localization and tissue temperature changes. After the procedure, T2-weighted and contrast material–enhanced T1-weighted MR imaging were performed to evaluate immediate and long-term effects.
RESULTS: Thermal imaging sequences were improved over the treatment period, with 82% (279 of 342) of the hot spots visible in the last seven treatments. The MR imager was used to measure temperature elevation (12.8°–49.9°C) from these treatments. Eight of the 11 lesions treated demonstrated complete or partial lack of contrast material uptake on posttherapy T1-weighted images. Three lesions showed no marked decrease of contrast material uptake. This lack of effective treatment was most likely due to a lower acoustic power and/or patient movement that caused misregistration. No adverse effects were detected, except for one case of transient edema in the pectoralis muscle 2 days after therapy.
CONCLUSION: MR imaging–guided FUS can be performed to noninvasively coagulate benign breast fibroadenomas.
Index terms: Breast neoplasms, MR, 00.121411, 00.121412, 00.121415, 00.12143 • Breast neoplasms, therapeutic radiology, 00.12986, 00.12989 • Breast neoplasms, therapeutic ultrasound (US), 00.12989, 00.311 • Breast neoplasms, US, 00.12986, 00.12989 • Fibroadenoma, 00.311
This article has been cited by other articles:
|
|
 |
|
  X.-L. Ren, X.-D. Zhou, R.-L. Yan, D. Liu, J. Zhang, G.-B. He, Z.-H. Han, M.-J. Zheng, and M. Yu Sonographically Guided Extracorporeal Ablation of Uterine Fibroids With High-Intensity Focused Ultrasound: Midterm Results J. Ultrasound Med., January 1, 2009; 28(1): 100 - 103. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gianfelice, C. Gupta, W. Kucharczyk, P. Bret, D. Havill, and M. Clemons Palliative Treatment of Painful Bone Metastases with MR Imaging-guided Focused Ultrasound Radiology, October 1, 2008; 249(1): 355 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Tempany From the RSNA Refresher Courses: Image-guided Thermal Therapy of Uterine Fibroids RadioGraphics, November 1, 2007; 27(6): 1819 - 1826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Hundt, E. L. Yuh, M. D. Bednarski, and S. Guccione Gene Expression Profiles, Histologic Analysis, and Imaging of Squamous Cell Carcinoma Model Treated with Focused Ultrasound Beams Am. J. Roentgenol., September 1, 2007; 189(3): 726 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kopelman and M. Papa Magnetic Resonance-Guided Focused Ultrasound Surgery for the Noninvasive Curative Ablation of Tumors and Palliative Treatments: A Review Ann. Surg. Oncol., May 1, 2007; 14(5): 1540 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P-Y Marcy, N Magne, P Castadot, C Bailet, and M Namer Ultrasound-guided percutaneous radiofrequency ablation in elderly breast cancer patients: preliminary institutional experience Br. J. Radiol., April 1, 2007; 80(952): 267 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vlastos and H. M. Verkooijen Minimally Invasive Approaches for Diagnosis and Treatment of Early-Stage Breast Cancer Oncologist, January 1, 2007; 12(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fujikura, R. Otsuka, A. Kalisz, J. A. Ketterling, Z. Jin, R. R. Sciacca, C. C. Marboe, J. Wang, R. Muratore, E. J. Feleppa, et al. Effects of ultrasonic exposure parameters on myocardial lesions induced by high-intensity focused ultrasound. J. Ultrasound Med., November 1, 2006; 25(11): 1375 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kinoshita, N. McDannold, F. A. Jolesz, and K. Hynynen Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption PNAS, August 1, 2006; 103(31): 11719 - 11723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. McDannold, C. M. Tempany, F. M. Fennessy, M. J. So, F. J. Rybicki, E. A. Stewart, F. A. Jolesz, and K. Hynynen Uterine Leiomyomas: MR Imaging-based Thermometry and Thermal Dosimetry during Focused Ultrasound Thermal Ablation. Radiology, July 1, 2006; 240(1): 263 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. K. Hesley, J. P. Felmlee, J. B. Gebhart, K. T. Dunagan, K. R. Gorny, J. B. Kesler, K. R. Brandt, J. N. Glantz, and B. S. Gostout Noninvasive Treatment of Uterine Fibroids: Early Mayo Clinic Experience With Magnetic Resonance Imaging-Guided Focused Ultrasound Mayo Clin. Proc., July 1, 2006; 81(7): 936 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Khiat, D Gianfelice, M Amara, and Y Boulanger Influence of post-treatment delay on the evaluation of the response to focused ultrasound surgery of breast cancer by dynamic contrast enhanced MRI. Br. J. Radiol., April 1, 2006; 79(940): 308 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gellermann, W. Wlodarczyk, B. Hildebrandt, H. Ganter, A. Nicolau, B. Rau, W. Tilly, H. Fahling, J. Nadobny, R. Felix, et al. Noninvasive Magnetic Resonance Thermography of Recurrent Rectal Carcinoma in a 1.5 Tesla Hybrid System Cancer Res., July 1, 2005; 65(13): 5872 - 5880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Jacobs, E. H. Herskovits, and H. S. Kim Uterine Fibroids: Diffusion-weighted MR Imaging for Monitoring Therapy with Focused Ultrasound Surgery--Preliminary Study Radiology, July 1, 2005; 236(1): 196 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Littrup, L. Freeman-Gibb, A. Andea, M. White, K. C. Amerikia, D. Bouwman, T. Harb, and W. Sakr Cryotherapy for Breast Fibroadenomas Radiology, January 1, 2005; 234(1): 63 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Roubidoux, M. S. Sabel, J. E. Bailey, C. G. Kleer, K. A. Klein, and M. A. Helvie Small (<2.0-cm) Breast Cancers: Mammographic and US Findings at US-guided Cryoablation--Initial Experience Radiology, December 1, 2004; 233(3): 857 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hindley, W. M. Gedroyc, L. Regan, E. Stewart, C. Tempany, K. Hynnen, N. Macdanold, Y. Inbar, Y. Itzchak, J. Rabinovici, et al. MRI Guidance of Focused Ultrasound Therapy of Uterine Fibroids: Early Results Am. J. Roentgenol., December 1, 2004; 183(6): 1713 - 1719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hashizume and K. Tsugawa Robotic Surgery and Cancer: the Present State, Problems and Future Vision Jpn. J. Clin. Oncol., May 1, 2004; 34(5): 227 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Sabel, C. S. Kaufman, P. Whitworth, H. Chang, L. H. Stocks, R. Simmons, and M. Schultz Cryoablation of Early-Stage Breast Cancer: Work-in-Progress Report of a Multi-Institutional Trial Ann. Surg. Oncol., May 1, 2004; 11(5): 542 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Fornage, N. Sneige, M. I. Ross, A. N. Mirza, H. M. Kuerer, B. S. Edeiken, F. C. Ames, L. A. Newman, G. V. Babiera, and S. E. Singletary Small (  [Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
N. McDannold, S. L. Fossheim, H. Rasmussen, H. Martin, N. Vykhodtseva, and K. Hynynen Heat-activated Liposomal MR Contrast Agent: Initial in Vivo Results in Rabbit Liver and Kidney Radiology, March 1, 2004; 230(3): 743 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ahmed, W. E. Monsky, G. Girnun, A. Lukyanov, G. D'Ippolito, J. B. Kruskal, K. E. Stuart, V. P. Torchilin, and S. N. Goldberg Radiofrequency Thermal Ablation Sharply Increases Intratumoral Liposomal Doxorubicin Accumulation and Tumor Coagulation Cancer Res., October 1, 2003; 63(19): 6327 - 6333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J E Kennedy, G R ter Haar, and D Cranston High intensity focused ultrasound: surgery of the future? Br. J. Radiol., September 1, 2003; 76(909): 590 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gianfelice, A. Khiat, M. Amara, A. Belblidia, and Y. Boulanger MR Imaging-guided Focused US Ablation of Breast Cancer: Histopathologic Assessment of Effectiveness—Initial Experience Radiology, June 1, 2003; 227(3): 849 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. C. Tempany, E. A. Stewart, N. McDannold, B. J. Quade, F. A. Jolesz, and K. Hynynen MR Imaging-guided Focused Ultrasound Surgery of Uterine Leiomyomas: A Feasibility Study Radiology, March 1, 2003; 226(3): 897 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Goldberg Comparison of Techniques for Image-guided Ablation of Focal Liver Tumors Radiology, May 1, 2002; 223(2): 304 - 307. [Full Text] [PDF]
|
|
|
|
|
|
P. E. Huber, J. W. Jenne, R. Rastert, I. Simiantonakis, H.-P. Sinn, H.-J. Strittmatter, D. von Fournier, M. F. Wannenmacher, and J. Debus A New Noninvasive Approach in Breast Cancer Therapy Using Magnetic Resonance Imaging-guided Focused Ultrasound Surgery Cancer Res., December 1, 2001; 61(23): 8441 - 8447. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
