| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cardiac Imaging |
1 From the Departments of Pediatric Cardiology (A.A.W.R., W.A.H.), Radiology (A.A.W.R., P.K., H.J.L., A.d.R.), Cardiology (A.A.W.R., H.W.V., E.E.v.d.W.), and Pulmonology (J.G.v.d.A.), Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands; and Interuniversity Cardiology Institute of the Netherlands, Utrecht (A.A.W.R., E.E.v.d.W., A.d.R.). Received May 14, 2001; revision requested June 15; revision received August 13; accepted September 28. Address correspondence to A.d.R. (e-mail: a.de_roos@lumc.nl).
PURPOSE: To assess the responses of pulmonary regurgitation (PR) and biventricular function to submaximal exercise by using a magnetic resonance (MR) imaging exercise protocol with young adult patients who underwent tetralogy of Fallot repair at a young age.
MATERIALS AND METHODS: Fifteen patients with corrected tetralogy of Fallot (mean age, 17.5 years ± 2.5 [SD]) underwent MR imaging at rest and during exercise for the evaluation of PR and biventricular function. Results were compared with findings from 16 control subjects (mean age, 17.5 years ± 2.3). Mean age at tetralogy of Fallot repair was 2.1 years ± 1.6, and mean follow-up time after repair was 15.4 years ± 2.6. Exercise level at MR imaging was calculated individually and corresponded to 60% of peak oxygen uptake. The parameters of cardiac function obtained at rest and during exercise were compared by using a paired t test. An unpaired t test was used to compare parameters of cardiac function between patients and control subjects.
RESULTS: PR decreased during exercise (from 27 mL/m2 ± 17 to 23 mL/m2 ± 15; P = .012). At rest, right ventricular (RV) ejection fraction was normal (>47%) in 80% of patients. RV response to exercise in the patient group was abnormal compared with response in the control group, as demonstrated by an increase in RV end-diastolic volume index (132 mL/m2 ± 36 to 137 mL/m2 ± 38; P = .041) and no significant change in end-systolic volume index or ejection fraction. In only one patient, RV ejection fraction increased by more than 5%. Left ventricular response was not different between patients and control subjects.
CONCLUSION: MR imaging is well suited to assess cardiac response to exercise, and findings revealed a decrease in PR and an abnormal RV response to exercise in patients with corrected tetralogy of Fallot.
© RSNA, 2002
Index terms: Pulmonary arteries, flow dynamics, 564.91 • Pulmonary arteries, MR, 564.12144 • Tetralogy of Fallot, 51.145, 51.452
This article has been cited by other articles:
|
|
 |
|
  J. van den Berg, W. C. Hop, J. L.M. Strengers, J. C. de Jongste, L. van Osch-Gevers, F. J. Meijboom, P. M.T. Pattynama, A. J.J.C. Bogers, and W. A. Helbing Clinical condition at mid-to-late follow-up after transatrial-transpulmonary repair of tetralogy of Fallot J. Thorac. Cardiovasc. Surg., February 1, 2007; 133(2): 470 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Oosterhof, B. J. M. Mulder, H. W. Vliegen, and A. de Roos Corrected Tetralogy of Fallot: Delayed Enhancement in Right Ventricular Outflow Tract Radiology, December 1, 2005; 237(3): 868 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Stewart, C. L. Backer, L. Young, and C. Mavroudis Tetralogy of Fallot: Results of a Pulmonary Valve-Sparing Strategy Ann. Thorac. Surg., October 1, 2005; 80(4): 1431 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Khambadkone, L. Coats, A. Taylor, Y. Boudjemline, G. Derrick, V. Tsang, J. Cooper, V. Muthurangu, S. R. Hegde, R. S. Razavi, et al. Percutaneous Pulmonary Valve Implantation in Humans: Results in 59 Consecutive Patients Circulation, August 23, 2005; 112(8): 1189 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oosterhof, J.W.J. Vriend, B.J.M. Mulder, A. Frigiola, S. Cullen, A. Redington, and M. Vogel Letter Regarding Article by Frigiola et al, "Pulmonary Regurgitation Is an Important Determinant of Right Ventricular Contractile Dysfunction in Patients With Surgically Repaired Tetralogy of Fallot" * Response Circulation, March 1, 2005; 111(8): e112 - e112. [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Pennell, U. P. Sechtem, C. B. Higgins, W. J. Manning, G. M. Pohost, F. E. Rademakers, A. C. van Rossum, L. J. Shaw, and E. K. Yucel Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report Eur. Heart J., November 1, 2004; 25(21): 1940 - 1965. [Full Text] [PDF]
|
|
|
|
|
|
A. Frigiola, A.N. Redington, S. Cullen, and M. Vogel Pulmonary Regurgitation Is an Important Determinant of Right Ventricular Contractile Dysfunction in Patients With Surgically Repaired Tetralogy of Fallot Circulation, September 14, 2004; 110(11_suppl_1): II-153 - II-157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Cheng, R. J. Herfkens, A. L. Lightner, C. A. Taylor, and J. A. Feinstein Blood flow conditions in the proximal pulmonary arteries and vena cavae: healthy children during upright cycling exercise Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H921 - H926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Geva, B. M. Sandweiss, K. Gauvreau, J. E. Lock, and A. J. Powell Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging J. Am. Coll. Cardiol., March 17, 2004; 43(6): 1068 - 1074. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
