HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lopez Hänninen, E. Articles by Felix, R. Search for Related Content PubMed PubMed Citation Articles by Lopez Hänninen, E. Articles by Felix, R.

Prospective Evaluation of Pancreatic Tumors: Accuracy of MR Imaging with MR Cholangiopancreatography and MR Angiography¹

¹ From the Departments of Radiology (E.L.H., H.A., N.H., J.R., R.F.), Visceral and Transplant Surgery (J.L., P.N.), and Gastroenterology and Hepatology (M.B., R.H., B.W, S.R.), Charité Medical University Center, Campus Virchow Clinic, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany. Received April 17, 2001; revision requested June 4; revision received August 27; accepted October 10. Address correspondence to E.L.H. (e-mail: enrique.lopez_haenninen@charite.de).

PURPOSE: To prospectively assess accuracy of magnetic resonance (MR) imaging, MR cholangiopancreatography (MRCP), and MR angiography in patients suspected of having pancreatic tumors.

MATERIALS AND METHODS: Sixty-six patients suspected of having pancreatic tumors underwent MR imaging (unenhanced and contrast material–enhanced MR, MRCP, and contrast-enhanced MR angiography). Two blinded readers prospectively analyzed the images by consensus, and results were correlated with surgery, biopsy, or follow-up findings. Results were tabulated in two-by-two tables.

RESULTS: MR assessment of pancreatic lesion status (differentiation of benign vs malignant) resulted in 60 correct diagnoses (accuracy, 91%), and six (10%) false diagnoses. Among histologically proved malignant tumors, MR imaging yielded correct diagnoses in 42 of 44 patients (sensitivity, 95%; 95% CI: 85%, 99%), whereas 18 of 22 patients with benign findings were classified correctly. At MR imaging, findings in four patients with chronic pancreatitis were wrongly categorized as malignant tumors (specificity, 82%; 95% CI: 60%, 95%), and in one patient, a distal common bile duct carcinoma was not detected. In no patient with pancreatic adenocarcinoma was this tumor misdiagnosed as benign. In patients with malignant tumors who underwent resection, local-regional tumor growth and vascular infiltration were accurately classified in 89% and 94%, respectively. MR imaging depicted histologically proved synchronous hepatic metastases in 82%. The positive and negative predictive values for cancer nonresectability were 90% and 83%, respectively, and the accuracy, sensitivity, and specificity were 85%, 69%, and 95%, respectively.

CONCLUSION: Unenhanced and contrast-enhanced MR imaging with MRCP and MR angiography offers potential as a noninvasive tool for assessment of patients suspected of having pancreatic tumors.

© RSNA, 2002

Index terms: Magnetic resonance (MR), cholangiopancreatography, 770.1222 • Magnetic resonance (MR), vascular studies, 770.12142 • Pancreas, MR, 770.121412, 770.121415, 770.12142 • Pancreas, neoplasms, 770.32, 770.364 • Pancreatitis, 770.291

This article has been cited by other articles:

				P Ghaneh, E Costello, and J P Neoptolemos Biology and management of pancreatic cancer Postgrad. Med. J., September 1, 2008; 84(995): 478 - 497. [Full Text] [PDF]

				P. Ghaneh, E. Costello, and J. P Neoptolemos Biology and management of pancreatic cancer Gut, August 1, 2007; 56(8): 1134 - 1152. [Full Text] [PDF]

				J. Ahualli The Double Duct Sign Radiology, July 1, 2007; 244(1): 314 - 315. [Full Text] [PDF]

				H. R. Cardenes, E. G. Chiorean, J. DeWitt, M. Schmidt, and P. Loehrer Locally advanced pancreatic cancer: current therapeutic approach. Oncologist, June 1, 2006; 11(6): 612 - 623. [Abstract] [Full Text] [PDF]

				Y. Mataki, S. Takao, K. Maemura, S. Mori, H. Shinchi, S. Natsugoe, and T. Aikou Carcinoembryonic Antigen Messenger RNA Expression Using Nested Reverse Transcription-PCR in the Peripheral Blood During Follow-up Period of Patients Who Underwent Curative Surgery for Biliary-Pancreatic Cancer: Longitudinal Analyses Clin. Cancer Res., June 1, 2004; 10(11): 3807 - 3814. [Abstract] [Full Text] [PDF]

				R. Sugita, A. Furuta, K. Ito, N. Fujita, R. Ichinohasama, and S. Takahashi Periampullary Tumors: High-Spatial-Resolution MR Imaging and Histopathologic Findings in Ampullary Region Specimens Radiology, June 1, 2004; 231(3): 767 - 774. [Abstract] [Full Text] [PDF]

				M K Kalra, M M Maher, P R Mueller, and S Saini State-of-the-art imaging of pancreatic neoplasms Br. J. Radiol., December 1, 2003; 76(912): 857 - 865. [Abstract] [Full Text] [PDF]