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Quantifying Sodium in the Human Wrist in Vivo by Using MR Imaging¹

¹ From the Department of Radiology, University of Pennsylvania, B1 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104-6100. Received June 13, 2001; revision requested August 6; revision received December 3; accepted January 22, 2002. This work was performed at an NIH-supported resource center (NIH RR02305) and supported by grants R01-AR45242 and R01-AR45404 from National Institutes of Arthritis, Musculoskeletal and Skin Diseases. Address correspondence to A.B. (e-mail: ari@mail.mmrrcc.upenn.edu).

The authors quantified sodium content in the wrist joints of six healthy volunteers with no known history of arthritis or pain. Average sodium concentrations ranged from 115 to 150 mmol/L in noncartilaginous regions and from 200 to 210 mmol/L in cartilaginous regions. The feasibility of quantifying sodium in vivo was demonstrated. This method has potential applications in monitoring the integrity of cartilaginous tissue in vivo.

© RSNA, 2002

Index terms: Cartilage, MR, 434.121412, 434.12146 • Magnetic resonance (MR), sodium studies, 434.121412, 434.12146 • Wrist, MR, 434.12146

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