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Effective Prophylactic Protocol in Delayed Hypersensitivity to Contrast Media: Report of a Case Involving Lymphocyte Transformation Studies with Different Compounds¹

¹ From the Department of Internal Medicine and Geriatrics, Universita’ Cattolica del Sacro Cuore, Allergy Unit, Complesso Integrato Columbus, Via G. Moscati 31, 00168 Rome, Italy (A.R., M.C.A., M.V.); Istituto di Ricovero e Cura a Carattere Scientifico, Oasi Maria S.S., Troina, Italy (A.R., M.A., R.P.); and Department of Radiology, UCSC, Rome, Italy (A.V.S.). Received October 10, 2001; revision requested December 20; revision received March 1, 2002; accepted March 14. Address correspondence to A.R. (e-mail: columbus.allerg@linet.it).

A patient with maculopapular reactions to iopamidol needed to undergo angiography for a cerebral arteriovenous malformation. In vivo and in vitro tests were performed with ionic and nonionic contrast media, including iopamidol and iobitridol. All results were positive, demonstrating delayed hypersensitivity. The patient received 6--methylprednisolone and cyclosporine 1 week before and 2 weeks after four angiograms were obtained with the use of iobitridol, which was well tolerated.

© RSNA, 2002

Index terms: Angiography, contrast media • Contrast media, comparative studies • Contrast media, complications

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