HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2263020041v1 226/3/773    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, S. G. Articles by Schnall, M. D. Search for Related Content PubMed PubMed Citation Articles by Lee, S. G. Articles by Schnall, M. D.

MR Imaging Screening of the Contralateral Breast in Patients with Newly Diagnosed Breast Cancer: Preliminary Results¹

¹ From the Departments of Radiology (S.G.L., S.G.O., M.D.S.), Biostatistics and Epidemiology (M.E.P.), Radiation Oncology (L.J.S.), and Surgery (B.J.C.), Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; Department of Radiology, Crozer-Chester Medical Center, Upland, Pa (I.J.W.); and Marques y Perez Radiologists, San Juan, PR (E.C.J.). Received February 5, 2002; revision requested April 10; revision received July 8; accepted August 15. Address correspondence to S.G.L. (e-mail: lees@rad.upenn.edu).

PURPOSE: To investigate the role of screening magnetic resonance (MR) imaging in the detection of synchronous contralateral breast cancer in patients with newly diagnosed breast cancer.

MATERIALS AND METHODS: Between January 1999 and July 2001, 182 patients with newly diagnosed breast cancer (after either core or excisional biopsy with positive or close margins of resection) underwent bilateral contrast material–enhanced MR imaging at 1.5 T with a dedicated bilateral breast multicoil array. The contralateral breast was imaged for cancer screening. Family history of breast cancer, index cancer histology, breast density, and age at diagnosis of first breast cancer were assessed as potential risk factors for synchronous contralateral breast cancer.

RESULTS: Fifteen patients (8.2%) had a suspicious enhancing lesion depicted in the contralateral breast. Seven patients (3.8%) had malignant results: ductal carcinoma in situ (DCIS) in four, invasive ductal carcinoma with DCIS in two, and invasive ductal carcinoma in one. Eight patients (4.4%) had benign results: fibrocystic changes in four, atypical ductal hyperplasia in two, atypical lobular hyperplasia and focal lobular carcinoma in situ in one, and ductal hyperplasia in one. Six patients with negative MR findings underwent prophylactic mastectomy; no malignancy was found. No significant differences were noted among patients with true-positive (n = 7), false-positive (n = 8), or negative (n = 167) MR findings with regard to family history of breast cancer (P < .27), index cancer histology (P < .19), breast density (P < .34), or age at diagnosis of first breast cancer (P < .10).

CONCLUSION: The preliminary results demonstrate the feasibility of using MR imaging of the breast in a screening role, specifically to evaluate the contralateral breast in patients with newly diagnosed breast cancer to detect mammographically and clinically occult synchronous breast cancer.

© RSNA, 2003

Index terms: Breast, MR, 00.121411, 00.121412, 00.121415, 00.12143 • Breast neoplasms, diagnosis, 00.30 • Magnetic resonance (MR), utilization, 00.30

This article has been cited by other articles:

				B.-K. Han, M. D. Schnall, S. G. Orel, and M. Rosen Outcome of MRI-Guided Breast Biopsy Am. J. Roentgenol., December 1, 2008; 191(6): 1798 - 1804. [Abstract] [Full Text] [PDF]

				S. Orel Who Should Have Breast Magnetic Resonance Imaging Evaluation? J. Clin. Oncol., February 10, 2008; 26(5): 703 - 711. [Abstract] [Full Text] [PDF]

				L. J. Solin, S. G. Orel, W.-T. Hwang, E. E. Harris, and M. D. Schnall Relationship of Breast Magnetic Resonance Imaging to Outcome After Breast-Conservation Treatment With Radiation for Women With Early-Stage Invasive Breast Carcinoma or Ductal Carcinoma in Situ J. Clin. Oncol., January 20, 2008; 26(3): 386 - 391. [Abstract] [Full Text] [PDF]

				D. Black, M. Specht, J. M. Lee, F. Dominguez, M. Gadd, K. Hughes, E. Rafferty, and B. Smith Detecting Occult Malignancy in Prophylactic Mastectomy: Preoperative MRI Versus Sentinel Lymph Node Biopsy Ann. Surg. Oncol., September 1, 2007; 14(9): 2477 - 2484. [Abstract] [Full Text] [PDF]

				C. K. Kuhl Current Status of Breast MR Imaging * Part 2. Clinical Applications Radiology, September 1, 2007; 244(3): 672 - 691. [Abstract] [Full Text] [PDF]

				C. Kuhl The Current Status of Breast MR Imaging * Part I. Choice of Technique, Image Interpretation, Diagnostic Accuracy, and Transfer to Clinical Practice Radiology, August 1, 2007; 244(2): 356 - 378. [Abstract] [Full Text] [PDF]

				T. C. Williams, W. B. DeMartini, S. C. Partridge, S. Peacock, and C. D. Lehman Breast MR Imaging: Computer-aided Evaluation Program for Discriminating Benign from Malignant Lesions Radiology, July 1, 2007; 244(1): 94 - 103. [Abstract] [Full Text] [PDF]

				F. Pediconi, C. Catalano, A. Roselli, S. Padula, F. Altomari, E. Moriconi, A. M. Pronio, M. A. Kirchin, and R. Passariello Contrast-enhanced MR Mammography for Evaluation of the Contralateral Breast in Patients with Diagnosed Unilateral Breast Cancer or High-Risk Lesions Radiology, June 1, 2007; 243(3): 670 - 680. [Abstract] [Full Text] [PDF]

				K. Y. Bilimoria, A. Cambic, N. M. Hansen, and K. P. Bethke Evaluating the Impact of Preoperative Breast Magnetic Resonance Imaging on the Surgical Management of Newly Diagnosed Breast Cancers Arch Surg, May 1, 2007; 142(5): 441 - 447. [Abstract] [Full Text] [PDF]

				C. D. Lehman, C. Gatsonis, C. K. Kuhl, R. E. Hendrick, E. D. Pisano, L. Hanna, S. Peacock, S. F. Smazal, D. D. Maki, T. B. Julian, et al. MRI Evaluation of the Contralateral Breast in Women with Recently Diagnosed Breast Cancer N. Engl. J. Med., March 29, 2007; 356(13): 1295 - 1303. [Abstract] [Full Text] [PDF]

				T. G. ODLE Breast MR Radiol. Technol., September 1, 2006; 78(1): 45M - 66M. [Abstract] [Full Text] [PDF]

				P. D. Friedman, S. V. Swaminathan, K. Herman, and L. Kalisher Breast MRI: the importance of bilateral imaging. Am. J. Roentgenol., August 1, 2006; 187(2): 345 - 349. [Full Text] [PDF]

				C. K. Kuhl, P. Jost, N. Morakkabati, O. Zivanovic, H. H. Schild, and J. Gieseke Contrast-enhanced MR Imaging of the Breast at 3.0 and 1.5 T in the Same Patients: Initial Experience Radiology, June 1, 2006; 239(3): 666 - 676. [Abstract] [Full Text] [PDF]

				N. Morakkabati-Spitz, H. H. Schild, C. C. Leutner, M. von Falkenhausen, G. Lutterbey, and C. K. Kuhl Dynamic Contrast-enhanced Breast MR Imaging in Men: Preliminary Results Radiology, December 21, 2005; (2005) 2382041312. [Abstract] [Full Text]

				C. K. Kuhl, H. H. Schild, and N. Morakkabati Dynamic Bilateral Contrast-enhanced MR Imaging of the Breast: Trade-off between Spatial and Temporal Resolution Radiology, September 1, 2005; 236(3): 789 - 800. [Abstract] [Full Text] [PDF]

				E. E. Deurloo, S. H. Muller, J. L. Peterse, A. P. E. Besnard, and K. G. A. Gilhuijs Clinically and Mammographically Occult Breast Lesions on MR Images: Potential Effect of Computerized Assessment on Clinical Reading Radiology, March 1, 2005; 234(3): 693 - 701. [Abstract] [Full Text] [PDF]

				W. A. Berg, L. Gutierrez, M. S. NessAiver, W. B. Carter, M. Bhargavan, R. S. Lewis, and O. B. Ioffe Diagnostic Accuracy of Mammography, Clinical Examination, US, and MR Imaging in Preoperative Assessment of Breast Cancer Radiology, December 1, 2004; 233(3): 830 - 849. [Abstract] [Full Text] [PDF]