Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print May 20, 2003, 10.1148/radiol.2281020718
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2281020718v1
228/1/235    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lencioni, R. A.
Right arrow Articles by Bartolozzi, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lencioni, R. A.
Right arrow Articles by Bartolozzi, C.
(Radiology 2003;228:235-240.)
© RSNA, 2003

Vascular and Interventional Radiology

Small Hepatocellular Carcinoma in Cirrhosis: Randomized Comparison of Radio-frequency Thermal Ablation versus Percutaneous Ethanol Injection1

Riccardo A. Lencioni, MD, Hans-Peter Allgaier, MD, Dania Cioni, MD, Manfred Olschewski, MSc, Peter Deibert, MD, Laura Crocetti, MD, Holger Frings, MD, Joerg Laubenberger, MD, Ina Zuber, MD, Hubert E. Blum, MD and Carlo Bartolozzi, MD

1 From the Division of Diagnostic and Interventional Radiology, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma 67, I-56125 Pisa, Italy (R.A.L., D.C., L.C., C.B.); and the Departments of Medicine II (H.P.A., P.D., H.F., I.Z., H.E.B.), Medical Biometry (M.O.), and Radiology (J.L.), University Hospital Freiburg, Germany. From the 2001 RSNA scientific assembly. Received June 17, 2002; revision requested August 8; final revision received November 26; accepted December 19. Address correspondence to R.A.L. (e-mail: lencioni@do.med.unipi.it).

PURPOSE: To compare the effectiveness of radio-frequency (RF) thermal ablation with that of percutaneous ethanol injection (PEI) for the treatment of small hepatocellular carcinoma (HCC) in patients with cirrhosis.

MATERIALS AND METHODS: A series of 102 patients with hepatic cirrhosis and either single HCC 5 cm in diameter or smaller or as many as three HCCs each 3 cm or smaller (overall number of lesions, 142) randomly received either RF ablation (n = 52) or PEI (n = 50) as the sole first-line anticancer treatment. Mean follow-up was 22.9 months ± 9.4 (SD) in the RF group and 22.4 months ± 8.6 in the PEI group. Prognostic value of treatment techniques was assessed with univariate and multivariate Cox proportional hazards regression models.

RESULTS: One- and 2-year survival rates were 100% and 98% in the RF group and 96% and 88% in the PEI group, respectively (univariate relative risk [RR] = 0.20; 95% CI: 0.02, 1.69; P = .138). One- and 2-year local recurrence-free survival rates were 98% and 96% in the RF group and 83% and 62% in the PEI group, respectively (univariate RR = 0.17; 95% CI: 0.06, 0.51; P = .002). One- and 2-year event-free survival rates were 86% and 64% for the RF group and 77% and 43% for the PEI group, respectively (univariate RR = 0.48; 95% CI: 0.27, 0.85; P = .012). RF treatment was confirmed as an independent prognostic factor for local recurrence-free survival rates with multivariate analysis (adjusted RR = 0.20; 95% CI: 0.05, 0.73; P = .015).

CONCLUSION: RF ablation is superior to PEI with respect to local recurrence-free survival rates.

© RSNA, 2003

Index terms: Alcohol ablation, 761.1266 • Liver, cirrhosis, 76.794 • Liver, interventional procedures, 761.1266, 761.1269 • Liver neoplasms, 76.323 • Radiofrequency (RF) ablation, 761.1269




This article has been cited by other articles:


Home page
 Therapeutic Advances in GastroenterologyHome page
K. E. Corey and D. S. Pratt
Review: Current status of therapy for hepatocellular carcinoma
Therapeutic Advances in Gastroenterology, January 1, 2009; 2(1): 45 - 57.
[Abstract] [PDF]

Home page
 Ann. Surg. Oncol.Home page
E. Berber and A. Siperstein
Local Recurrence After Laparoscopic Radiofrequency Ablation of Liver Tumors: An Analysis of 1032 Tumors
Ann. Surg. Oncol., October 1, 2008; 15(10): 2757 - 2764.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. de Baere, F. Deschamps, P. Briggs, C. Dromain, V. Boige, L. Hechelhammer, M. Abdel-Rehim, A. Auperin, D. Goere, and D. Elias
Hepatic Malignancies: Percutaneous Radiofrequency Ablation during Percutaneous Portal or Hepatic Vein Occlusion
Radiology, September 1, 2008; 248(3): 1056 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. K. Kei, H. Rhim, D. Choi, W. J. Lee, H. K. Lim, and Y.-s. Kim
Local Tumor Progression After Radiofrequency Ablation of Liver Tumors: Analysis of Morphologic Pattern and Site of Recurrence
Am. J. Roentgenol., June 1, 2008; 190(6): 1544 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. Rhim, M. H. Lee, Y.-s. Kim, D. Choi, W. J. Lee, and H. K. Lim
Planning Sonography to Assess the Feasibility of Percutaneous Radiofrequency Ablation of Hepatocellular Carcinomas
Am. J. Roentgenol., May 1, 2008; 190(5): 1324 - 1330.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
J. Belghiti, B. I. Carr, P. D. Greig, R. Lencioni, and R. T. Poon
Treatment before Liver Transplantation for HCC
Ann. Surg. Oncol., April 1, 2008; 15(4): 993 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. Yamakado, A. Nakatsuka, H. Takaki, H. Yokoi, M. Usui, H. Sakurai, S. Isaji, K. Shiraki, H. Fuke, S. Uemoto, et al.
Early-Stage Hepatocellular Carcinoma: Radiofrequency Ablation Combined with Chemoembolization versus Hepatectomy
Radiology, April 1, 2008; 247(1): 260 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. N. Wong, C.-J. Lin, C.-C. Lin, W.-T. Chen, I. H. Y. Cua, and S.-M. Lin
Combined Percutaneous Radiofrequency Ablation and Ethanol Injection for Hepatocellular Carcinoma in High-Risk Locations
Am. J. Roentgenol., March 1, 2008; 190(3): W187 - W195.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
M.-h. Park, H. Rhim, Y.-s. Kim, D. Choi, H. K. Lim, and W. J. Lee
Spectrum of CT Findings after Radiofrequency Ablation of Hepatic Tumors
RadioGraphics, March 1, 2008; 28(2): 379 - 390.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. Rhim, H. K. Lim, Y.-s. Kim, and D. Choi
Percutaneous Radiofrequency Ablation with Artificial Ascites for Hepatocellular Carcinoma in the Hepatic Dome: Initial Experience
Am. J. Roentgenol., January 1, 2008; 190(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
J. Shao, J. Bai, L. Cui, J. Wang, Y. Fu, K. Liu, and S. Feng
Elastographic Evaluation of the Temporal Formation of Ethanol-Induced Hepatic Lesions: Preliminary In Vitro Results
J. Ultrasound Med., September 1, 2007; 26(9): 1191 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
D. Choi, H. K. Lim, H. Rhim, Y.-s. Kim, B. C. Yoo, S. W. Paik, J.-W. Joh, and C. K. Park
Percutaneous Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma After Hepatectomy: Long-term Results and Prognostic Factors
Ann. Surg. Oncol., August 1, 2007; 14(8): 2319 - 2329.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
Y.-J. Zhang, H.-H. Liang, M.-S. Chen, R.-P. Guo, J.-Q. Li, Y. Zheng, Y.-Q. Zhang, and W. Y. Lau
Hepatocellular Carcinoma Treated with Radiofrequency Ablation with or without Ethanol Injection: A Prospective Randomized Trial
Radiology, August 1, 2007; 244(2): 599 - 607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
P. F. Laeseke, T. M. Frey, C. L. Brace, L. A. Sampson, T. C. Winter III, J. R. Ketzler, and F. T. Lee Jr.
Multiple-Electrode Radiofrequency Ablation of Hepatic Malignancies: Initial Clinical Experience
Am. J. Roentgenol., June 1, 2007; 188(6): 1485 - 1494.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
S.-Y. Chiou, J.-B. Liu, and L. Needleman
Current Status of Sonographically Guided Radiofrequency Ablation Techniques
J. Ultrasound Med., April 1, 2007; 26(4): 487 - 499.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. M. Maher, P. A. Hodnett, and M. K. Kalra
Evidence-based Practice in Radiology: Steps 3 and 4--Appraise and Apply Interventional Radiology Literature
Radiology, March 1, 2007; 242(3): 658 - 670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
T. Nakazawa, S. Kokubu, A. Shibuya, K. Ono, M. Watanabe, H. Hidaka, T. Tsuchihashi, and K. Saigenji
Radiofrequency Ablation of Hepatocellular Carcinoma: Correlation Between Local Tumor Progression After Ablation and Ablative Margin
Am. J. Roentgenol., February 1, 2007; 188(2): 480 - 488.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. F. Laeseke, L. A. Sampson, D. Haemmerich, C. L. Brace, J. P. Fine, T. M. Frey, T. C. Winter III, and F. T. Lee Jr
Multiple-Electrode Radiofrequency Ablation Creates Confluent Areas of Necrosis: In Vivo Porcine Liver Results
Radiology, October 1, 2006; 241(1): 116 - 124.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. d. Baere, J. Palussiere, A. Auperin, A. Hakime, M. Abdel-Rehim, M. Kind, C. Dromain, A. Ravaud, N. Tebboune, V. Boige, et al.
Midterm Local Efficacy and Survival after Radiofrequency Ablation of Lung Tumors with Minimum Follow-up of 1 Year: Prospective Evaluation.
Radiology, August 1, 2006; 240(2): 587 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. Shibuya, T. Nakazawa, K. Saigenji, K. Furuta, and K. Matsunaga
Diaphragmatic hernia after radiofrequency ablation therapy for hepatocellular carcinoma.
Am. J. Roentgenol., May 1, 2006; 186(5 Suppl): S241 - S243.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
Y. K. Cho, H. Rhim, Y. S. Ahn, M. Y. Kim, and H. K. Lim
Percutaneous radiofrequency ablation therapy of hepatocellular carcinoma using multitined expandable electrodes: comparison of subcapsular and nonsubcapsular tumors.
Am. J. Roentgenol., May 1, 2006; 186(5 Suppl): S269 - S274.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. L. Hinshaw, P. F. Laeseke, T. C. Winter III, M. A. Kliewer, J. P. Fine, and F. T. Lee Jr.
Radiofrequency ablation of peripheral liver tumors: intraperitoneal 5% dextrose in water decreases postprocedural pain.
Am. J. Roentgenol., May 1, 2006; 186(5 Suppl): S306 - S310.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
L. M. Sutherland, J. A. R. Williams, R. T. A. Padbury, D. C. Gotley, B. Stokes, and G. J. Maddern
Radiofrequency ablation of liver tumors: a systematic review.
Arch Surg, February 1, 2006; 141(2): 181 - 190.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Zerbini, M. Pilli, A. Penna, G. Pelosi, C. Schianchi, A. Molinari, S. Schivazappa, C. Zibera, F. F. Fagnoni, C. Ferrari, et al.
Radiofrequency Thermal Ablation of Hepatocellular Carcinoma Liver Nodules Can Activate and Enhance Tumor-Specific T-Cell Responses
Cancer Res., January 15, 2006; 66(2): 1139 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. Shibata, T. Shibata, Y. Maetani, H. Isoda, and M. Hiraoka
Radiofrequency Ablation for Small Hepatocellular Carcinoma: Prospective Comparison of Internally Cooled Electrode and Expandable Electrode
Radiology, January 1, 2006; 238(1): 346 - 353.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Staunton, J. D. Dodd, P. A. McCormick, and D. E. Malone
Finding Evidence-based Answers to Practical Questions in Radiology: Which Patients with Inoperable Hepatocellular Carcinoma Will Survive Longer after Transarterial Chemoembolization?
Radiology, November 1, 2005; 237(2): 404 - 413.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S-M Lin, C-J Lin, C-C Lin, C-W Hsu, and Y-C Chen
Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less
Gut, August 1, 2005; 54(8): 1151 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
K. K. Tanabe, L. S. Blaszkowsky, R. T. Chung, M. A. Blake, and G. Y. Lauwers
Case 23-2005 - A 57-Year-Old Man with a Mass in the Liver
N. Engl. J. Med., July 28, 2005; 353(4): 401 - 410.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D. Choi, H. K. Lim, M. J. Kim, S. J. Kim, S. H. Kim, W. J. Lee, J. H. Lim, S. W. Paik, B. C. Yoo, M. S. Choi, et al.
Liver Abscess After Percutaneous Radiofrequency Ablation for Hepatocellular Carcinomas: Frequency and Risk Factors
Am. J. Roentgenol., June 1, 2005; 184(6): 1860 - 1867.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Kawashima, J. Furuse, T. Nishio, M. Konishi, H. Ishii, T. Kinoshita, M. Nagase, K. Nihei, and T. Ogino
Phase II Study of Radiotherapy Employing Proton Beam for Hepatocellular Carcinoma
J. Clin. Oncol., March 20, 2005; 23(9): 1839 - 1846.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. Lencioni, D. Cioni, L. Crocetti, C. Franchini, C. D. Pina, J. Lera, and C. Bartolozzi
Early-Stage Hepatocellular Carcinoma in Patients with Cirrhosis: Long-term Results of Percutaneous Image-guided Radiofrequency Ablation
Radiology, March 1, 2005; 234(3): 961 - 967.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. M. Lee, J. K. Han, S. H. Kim, S. H. Choi, S. K. An, C. J. Han, and B. I. Choi
Bipolar Radiofrequency Ablation Using Wet-Cooled Electrodes: An In Vitro Experimental Study in Bovine Liver
Am. J. Roentgenol., February 1, 2005; 184(2): 391 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. Giorgio, L. Tarantino, G. de Stefano, C. Coppola, and G. Ferraioli
Complications After Percutaneous Saline-Enhanced Radiofrequency Ablation of Liver Tumors: 3-Year Experience with 336 Patients at a Single Center
Am. J. Roentgenol., January 1, 2005; 184(1): 207 - 211.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
O. Seror, G. N'Kontchou, D. Haddar, M. Dordea, Y. Ajavon, N. Ganne, J. C. Trinchet, M. Beaugrand, and N. Sellier
Large Infiltrative Hepatocellular Carcinomas: Treatment with Percutaneous Intraarterial Ethanol Injection Alone or in Combination with Conventional Percutaneous Ethanol Injection
Radiology, January 1, 2005; 234(1): 299 - 309.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. O. Stolberg, G. Norman, and I. Trop
Randomized Controlled Trials
Am. J. Roentgenol., December 1, 2004; 183(6): 1539 - 1544.
[Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
J M Lee, J K Han, S H Kim, J Y Lee, S H Choi, and B I Choi
Hepatic bipolar radiofrequency ablation using perfused-cooled electrodes: a comparative study in the ex vivo bovine liver
Br. J. Radiol., November 1, 2004; 77(923): 944 - 949.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D. Choi, H. K. Lim, M. J. Kim, S. H. Kim, W. J. Lee, S. H. Kim, J. H. Lim, S. W. Paik, K. C. Koh, and B. C. Yoo
Therapeutic Efficacy and Safety of Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma Abutting the Gastrointestinal Tract
Am. J. Roentgenol., November 1, 2004; 183(5): 1417 - 1424.
[Abstract] [Full Text] [PDF]

Home page
 ImagingHome page
J A Guthrie
Cirrhosis and focal liver lesions: MRI findings
Imaging, September 1, 2004; 16(4): 351 - 363.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Breuhahn, S. Vreden, R. Haddad, S. Beckebaum, D. Stippel, P. Flemming, T. Nussbaum, W. H. Caselmann, B. B. Haab, and P. Schirmacher
Molecular Profiling of Human Hepatocellular Carcinoma Defines Mutually Exclusive Interferon Regulation and Insulin-Like Growth Factor II Overexpression
Cancer Res., September 1, 2004; 64(17): 6058 - 6064.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
A R Gillams
Liver ablation therapy
Br. J. Radiol., September 1, 2004; 77(921): 713 - 723.
[Full Text] [PDF]

Home page
 RadiologyHome page
A. Giorgio, G. Ferraioli, and R. A. Lencioni
Radiofrequency Thermal Ablation versus Percutaneous Ethanol Injection for Small Hepatocellular Carcinoma [letter] * Dr Lencioni and colleagues respond:
Radiology, March 1, 2004; 230(3): 886 - 887.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2003 by the Radiological Society of North America.