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Osteogenic and Ewing Sarcomas: Estimation of Necrotic Fraction during Induction Chemotherapy with Dynamic Contrast-enhanced MR Imaging¹

¹ From the Department of Radiology (J.P.D., D.M.P, L.H.S., D.B.), Weill Medical College of Cornell University, 1300 York Ave, Box 234, New York, NY 10021-4885; Departments of Radiology (D.M.P., L.H.S., J.A.K., D.B.), Surgery (J.H.H.), Pediatrics (P.A.M., R.G.), Pathology (A.G.H.), Biostatistics (H.T.T.), Medical Physics (J.A.K., D.B.), and Medicine (J.A.K.), Memorial Sloan-Kettering Cancer Center, New York, NY; and Institute of Neurology, University College London, England (P.S.T.). Received October 9, 2001; revision requested January 2, 2002; final revision received October 16; accepted November 6. Supported in part by National Institutes of Health grants R01HL50139, CA05826-038A1, and RO1CA62556. Address correspondence to J.P.D. (e-mail: jpd2001@med.cornell.edu).

Dynamic contrast material–enhanced magnetic resonance (MR) images of primary osteogenic sarcoma (n = 19) and Ewing sarcoma (n = 10) were reviewed in 29 patients undergoing induction chemotherapy before surgery. Histogram distributions containing the initial slope and pharmacokinetic model parameters from individual voxels within each tumor were fitted for each patient. The histogram analysis of initial slope from the tumor correlated well with percentage necrosis as determined at pathologic examination (r = 0.60, P < .001), as did a two-compartment pharmacokinetic model (r = 0.64, P < .001). Both methods predicted tumors with clinically important degrees of necrosis (ie, ≥90%) in a large majority of cases. The ability to determine response to induction chemotherapy by means of noninvasive monitoring of necrotic fraction with perfusion MR imaging methods may provide useful prognostic information and help surgical planning.

© RSNA, 2003

Index terms: Bone neoplasms, MR, 41.12143, 44.12143, 45.12143 • Chemotherapy, 41.3221, 41.3281, 44.3221, 44.3281, 45.3221, 45.3281 • Ewing sarcoma, 41.3281, 44.3281, 45.3281 • Osteosarcoma, 41.3221, 44.3221, 45.3221

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