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DOI: 10.1148/radiol.2283020059
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(Radiology 2003;228:864-870.)
© RSNA, 2003


Technical Developments

Small Pulmonary Nodules: Volume Measurement at Chest CT—Phantom Study1

Jane P. Ko, MD, Henry Rusinek, PhD, Erika L. Jacobs, MD, James S. Babb, PhD, Margrit Betke, PhD, Georgeann McGuinness, MD and David P. Naidich, MD

1 From the Department of Radiology, Section of Thoracic Imaging, New York University Medical Center, 560 1st Ave, New York, NY 10016 (J.P.K., H.R., E.L.J., G.M., D.P.N.); Fox Chase Cancer Center, Philadelphia, Pa (J.S.B.); and Computer Science Department, Boston University, Mass (M.B.). From the 2001 RSNA scientific assembly. Received February 7, 2002; revision requested April 15; final revision received October 28; accepted December 19. Supported by a Scholars Award from the RSNA Research and Education Foundation and a Seed Grant from the Society of Thoracic Radiology. Address correspondence to J.P.K. (e-mail: jane.ko@med.nyu.edu).

Three-dimensional methods for quantifying pulmonary nodule volume at computed tomography (CT) and the effect of imaging variables were studied by using a realistic phantom. Two fixed-threshold methods, a partial-volume method (PVM) and a variable method, were used to calculate volumes of 40 plastic nodules (largest dimension, <5 mm: 20 nodules with solid attenuation and 20 with ground-glass attenuation) of known volume. Tube current times (20 and 120 mAs), reconstruction algorithms (high and low frequency), and nodule characteristics were studied. Higher precision was associated with use of a PVM with predetermined pure nodule attenuation, high-frequency algorithm, and diagnostic CT technique (120 mAs). A PVM is promising for volume quantification and follow-up of nodules.

© RSNA, 2003

Index terms: Computed tomography (CT), image processing, 60.12117 • Computed tomography (CT), technology, 60.12117 • Images, analysis, 60.12117 • Lung, CT, 60.12117 • Lung, nodule, 60.12117




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