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1 From the Department of Radiology, Section of Thoracic Imaging, New York University Medical Center, 560 1st Ave, New York, NY 10016 (J.P.K., H.R., E.L.J., G.M., D.P.N.); Fox Chase Cancer Center, Philadelphia, Pa (J.S.B.); and Computer Science Department, Boston University, Mass (M.B.). From the 2001 RSNA scientific assembly. Received February 7, 2002; revision requested April 15; final revision received October 28; accepted December 19. Supported by a Scholars Award from the RSNA Research and Education Foundation and a Seed Grant from the Society of Thoracic Radiology. Address correspondence to J.P.K. (e-mail: jane.ko@med.nyu.edu).
Three-dimensional methods for quantifying pulmonary nodule volume at computed tomography (CT) and the effect of imaging variables were studied by using a realistic phantom. Two fixed-threshold methods, a partial-volume method (PVM) and a variable method, were used to calculate volumes of 40 plastic nodules (largest dimension, <5 mm: 20 nodules with solid attenuation and 20 with ground-glass attenuation) of known volume. Tube current times (20 and 120 mAs), reconstruction algorithms (high and low frequency), and nodule characteristics were studied. Higher precision was associated with use of a PVM with predetermined pure nodule attenuation, high-frequency algorithm, and diagnostic CT technique (120 mAs). A PVM is promising for volume quantification and follow-up of nodules.
© RSNA, 2003
Index terms: Computed tomography (CT), image processing, 60.12117 Computed tomography (CT), technology, 60.12117 Images, analysis, 60.12117 Lung, CT, 60.12117 Lung, nodule, 60.12117
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