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System for MR Image–guided Prostate Interventions: Canine Study¹

¹ From the Departments of Biomedical Engineering (R.C.S., E.A.), Mechanical Engineering (A.K., L.L.W.), Computer Science (A.T., G.F.), and Radiology (E.A.), Johns Hopkins University School of Medicine, 720 Rutland Ave, Traylor Bldg 330, Baltimore, MD 21205; Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Md (J.A.D.); and Department of Electrical Engineering, Bilkent University, Ankara, Turkey (E.A.). Received July 31, 2002; revision requested September 30; revision received October 28; accepted December 10. Supported in part by NIH grants R01 HL57483 and R01 HL61672. Additional support from NSF grant ERC 9731478 and U.S. Army grant PC 10029. R.C.S. supported by an NIH training grant. Address correspondence to E.A. (e-mail: eatalar@mri.jhu.edu).

The purpose of this study was to demonstrate the use of a transrectal system that enables precise magnetic resonance (MR) image guidance and monitoring of prostate interventions. The system used a closed-bore 1.5-T MR imaging unit and enables one to take advantage of the higher signal-to-noise ratio achieved with traditional magnet designs, which is crucial for accurate targeting and monitoring of prostate interventions. In the first of the four canine studies, reliable needle placement, with all needles placed within 2 mm of the desired target site, was achieved. In two other studies, MR imaging was used to monitor distribution of injected contrast agent solution (gadopentetate dimeglumine mixed with trypan blue dye) in and around the prostate, thereby confirming that solution had been delivered to the desired tissue and also detecting faulty injections. In the final study, accurate placement and MR imaging of brachytherapy seeds in the prostate were demonstrated. The described system provides a flexible platform for a variety of minimally invasive MR image–guided therapeutic and diagnostic prostate interventions.

© RSNA, 2003

Index terms: Magnetic resonance (MR), experimental studies, 844.121411, 844.121412, 844.121416, 844.12143, 844.12149 • Magnetic resonance (MR), guidance, 844.121411, 844.121412, 844.121416, 844.12143, 844.12149 • Prostate neoplasms • Prostate neoplasms, MR, 844.121411, 844.121412, 844.121416, 844.12143, 844.12149 • Prostate neoplasms, therapeutic radiology, 844.12149

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