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Brachial Artery: Measurement of Flow-mediated Dilatation with Cross-sectional US—Technical Validation¹

¹ From the Departments of Radiology (Y.H.K., P.H.A., C.M.S.) and Medicine (E.R.M.), University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce St, Philadelphia, PA 19104. Received August 1, 2002; revision requested October 7; revision received November 8; accepted December 10. Address correspondence to C.M.S. (e-mail: sehgal@oasis.rad.upenn.edu).

Ultrasonographic examination of flow phantoms and the brachial artery of a healthy volunteer undergoing reactive hyperemia was performed. Images were analyzed with a user-guided automated boundary detection (UGABD) algorithm to extract boundaries and measure cross-sectional area. UGABD correctly detected pulsatile vasomotion and measured area within 5% of the true value. A comparison of UGABD versus manual tracing yielded linear correlation of 0.81–0.91. Peak vasodilatation measured in response to reactive hyperemia was 150 times greater in pixel count than that measured with longitudinal imaging. Cross-sectional imaging is more sensitive than longitudinal imaging for measuring flow-mediated dilatation of the brachial artery.

© RSNA, 2003

Index terms: Arteries, extremities, 912.1298 • Arteries, US, 912.1298 • Blood, flow dynamics • Computers • Phantoms

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