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Coronary Arteries: Contrast-enhanced MR Imaging with SH L 643A—Experience in 12 Volunteers¹

¹ From the Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany (C.U.H., J.B., P.H.); German Heart Institute, Berlin, Germany (I.P., E.N.); Schering, Berlin, Germany (M.M.); and Berlex, Montville, NJ (K.S.). Received August 20, 2002; revision requested October 21; revision received November 18; accepted January 27, 2003. Address correspondence to J.B. (e-mail: joerg.barkhausen@uni-essen.de).

PURPOSE: To assess SH L 643A for three-dimensional breath-hold and respiratory-gated magnetic resonance (MR) imaging in the depiction of coronary arteries.

MATERIALS AND METHODS: Twelve healthy male volunteers underwent either three-dimensional breath-hold (n = 6) or respiratory-gated (n = 6) coronary MR angiography before and after intravenous injection of 0.1 mmol SH L 643A per kilogram of body weight. For nonenhanced and contrast material–enhanced examinations, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements were obtained. Image quality was assessed in consensus with a five-point scale. Statistical analysis of nonenhanced and contrast-enhanced images was based on a two-tailed paired Student t test. A P value at the .05 significance level was used.

RESULTS: Overall statistically significant improvement in CNR was observed after administration of SH L 643A compared with that on nonenhanced images (8.7 ± 5.3 [SD] vs 23.6 ± 7.2, P < .01). While SNR of contrast-enhanced images showed improvement over that of nonenhanced images, the difference was not statistically significant (25.4 ± 0.8 vs 30.2 ± 16.8, P > .2). Image quality improved from a mean of 3.1 ± 0.8 for nonenhanced images to 4.0 ± 0.8 (P < .01) for contrast-enhanced images.

CONCLUSION: SH L 643A causes significant improvement of the blood-myocardium contrast enhancement at coronary MR angiography compared with that with nonenhanced sequences.

© RSNA, 2003

Index terms: Coronary angiography, contrast media, 511.12142, 511.12143 • Coronary vessels, MR, 54.121412, 54.121413, 54.12142, 54.12143 • Gadolinium • Magnetic resonance (MR), contrast enhancement, 511.12143 • Magnetic resonance (MR), contrast media, 511.12143

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