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DOI: 10.1148/radiol.2291021041
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(Radiology 2003;229:269-274.)
© RSNA, 2003

Technical Developments

In Vivo Proton MR Three-dimensional T1{rho} Mapping of Human Articular Cartilage: Initial Experience1

Ravinder Reddy Regatte, PhD, Sarma V. S. Akella, PhD, Arijitt Borthakur, PhD, J. Bruce Kneeland, MD and Ravinder Reddy, PhD

1 From the MMRRCC, Department of Radiology, B1, Stellar-Chance Laboratories, University of Pennsylvania Medical Center, 422 Curie Blvd, Philadelphia, PA 19104-6100. Received August 26, 2002; revision requested October 18; revision received December 2; accepted February 3, 2003. Supported by NIH research resource grant RR02305, grants R0145242 and R0145404 from National Institutes of Arthritis and Musculoskeletal and Skin Diseases, and the Arthritis Foundation. Address correspondence to R.R.R. (e-mail: regatte@mail.mmrrcc.upenn.edu).

The purpose of this study was to demonstrate the feasibility of computing three-dimensional relaxation maps of spin-lattice relaxation time in the rotating frame (T1{rho}) from in vivo magnetic resonance (MR) images of the human patellofemoral joint. T1{rho} was measured by applying a three-dimensional gradient-echo pulse sequence in six healthy subjects and one symptomatic subject by using a 1.5-T MR imager and a 15-cm–diameter transmit-receive quadrature birdcage radiofrequency coil. Average T1{rho} measured in healthy patellar cartilage was 49.7 msec ± 3.2 (mean ± SD). Two-dimensional T1{rho}-weighted images were obtained with a fast spin-echo pulse sequence for comparison. There was good correlation between two-dimensional and three-dimensional T1{rho} values for the six healthy subjects (R2 = 0.88, slope = 1.16).

© RSNA, 2003

Index terms: Arthritis, 45.77 • Cartilage, MR, 45.12141 • Magnetic resonance (MR), three-dimensional




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