HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maataoui, A. Articles by Vogl, T. J. Search for Related Content PubMed PubMed Citation Articles by Maataoui, A. Articles by Vogl, T. J. Related Collections Related Article

Liver Metastases in Rats: Chemoembolization Combined with Interstitial Laser Ablation for Treatment¹

¹ From the Institute for Diagnostic and Interventional Radiology (A.M., J.Q., M.G.M., M.F.K., M.R., S.S., T.J.V.) and Department of Visceral Surgery (E.O., W.O.B.), Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Received August 30, 2004; revision requested October 29; revision received December 23; accepted January 24, 2005. Address correspondence to A.M. (e-mail: adel.maataoui{at}gmx.de).

PURPOSE: To assess the effect of transcatheter arterial chemoembolization (TACE) combined with laser-induced thermotherapy (LITT) for treatment of liver metastases in an animal model.

MATERIALS AND METHODS: All experiments were approved by the German government and the institutional animal research review board. After subcapsular liver implantation of colorectal cancer cells in 30 WAG rats (on day 0), the animals were randomly assigned to three interventional treatment groups. In the 10 rats in group A, TACE was performed: Fourteen days after cancer cell implantation and within 20 minutes after laparotomy and retrograde placement of a microcatheter into the gastroduodenal artery, these rats were injected with mitomycin (0.1 mg), iodized oil (0.1 mL), and degradable starch microspheres (5.0 mg). In the 10 rats in group B, LITT was performed: Also on day 14, the tumors in these animals were exposed to Nd:YAG laser light of 1064 nm at 2 W for 5 minutes. In the 10 rats in group C, combined treatment was administered: TACE was performed on day 14, and LITT was performed on day 21. Tumor volumes were measured before (on day 13) and after (on day 28) treatment with magnetic resonance (MR) imaging, and the mean tumor growth ratio (day 13 tumor volume divided by day 28 tumor volume) was calculated.

RESULTS: The mean tumor volumes measured before and after the treatments were, respectively, 0.11 and 0.60 cm³ in group A, 0.11 and 0.68 cm³ in group B, and 0.11 and 0.35 cm³ in group C. The mean tumor growth ratio was 5.42 in group A, 6.14 in group B, and 3.15 in group C. According to Bonferroni test results, compared with the rats in groups A and B (controls), the group C rats had significantly inhibited tumor growth (P < .01 for both comparisons).

CONCLUSION: Use of combined TACE-LITT treatment, compared with the use of TACE or LITT alone, significantly inhibits tumor growth.

© RSNA, 2005

Related Article

Can Combination Therapy for Colorectal Liver Metastases Improve Results over Chemoembolization or Ablation Alone?

Scott O. Trerotola
Radiology 2005 237: 381-382. [Full Text] [PDF]

This article has been cited by other articles:

				S. O. Trerotola Can Combination Therapy for Colorectal Liver Metastases Improve Results over Chemoembolization or Ablation Alone? Radiology, November 1, 2005; 237(2): 381 - 382. [Full Text] [PDF]