HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Alderson, P. O. Articles by Treves, S. T. Search for Related Content PubMed PubMed Citation Articles by Alderson, P. O. Articles by Treves, S. T.

Radioaerosol Scintigraphy in Infants and Children Born to Mothers with HIV Disease

¹ From Depts of Radiology (P.O.A., M.J.F.)
² Pediatrics (R.B.M.), Columbia-Presbyterian Medical Center, 622 W 168th St, New York, NY 10032
³ Dept of Radiology, Univ of Southern California Medical Center (D.C.P.C.)
⁴ Dept of Radiology, Univ of California, Los Angeles Medical Center and School of Medicine (C.K.H.)
⁵ Dept of Radiology, Mount Sinai Medical Center and School of Medicine, New York (C.K.K.)
⁶ Dept of Radiology, Boston City Hospital, Mass (V.W.L.)
⁷ Dept of Radiology, Children's Hospital, Los Angeles, Calif (J.H.M.)
⁸ Dept of Radiology, Texas Children's Hospital, Houston (W.H.M.)
⁹ Div of Lung Diseases, National Heart, Lung and Blood Institute, Bethesda, Md (H.H.P.)
¹⁰ Dept of Biostatistics and Epidemiology, Cleveland Clinic, Ohio (A.S.)
¹¹ Div of Nuclear Medicine, Children's Hospital, Harvard Medical School, Boston, Mass (S.T.T.).

View larger version (132K): [in a new window]   Figure 1. Posterior 99mTc DTPA radioaerosol image obtained over the thorax at the end of the inhalation period. This 4-year-old boy in group 1 had a relatively benign course and was alive 5 years after this study was obtained. Regions of interest (solid and dotted lines) outline each lung. Deposition in the lungs is uniform. A chest radiograph obtained the previous day (not shown) showed clear lungs. The 99mTc DTPA clearance half-time was 56.5 minutes, which is normal.

View larger version (131K): [in a new window]   Figure 2a. (a) Posterior 99mTc DTPA radioaerosol image obtained over the thorax at the end of the inhalation period. This 10-month-old group 1 male infant was studied approximately 2 months before the onset of a terminal illness that included respiratory distress and sepsis. Peripheral deposition of 99mTc DTPA was uniform, but there was moderate central airway hyperdeposition (arrowheads). The outlined regions of interest were modified to avoid these areas. (b) Graph of clearance analysis data reveals accelerated 99mTc DTPA egress (half-time [T1/2], 27.9 minutes). The dotted line represents the clearance function fit to the first 8 minutes of data; the solid line represents the actual data. There was no chest radiograph obtained near the time the radioaerosol study was obtained.

View larger version (15K): [in a new window]   Figure 2b. (a) Posterior 99mTc DTPA radioaerosol image obtained over the thorax at the end of the inhalation period. This 10-month-old group 1 male infant was studied approximately 2 months before the onset of a terminal illness that included respiratory distress and sepsis. Peripheral deposition of 99mTc DTPA was uniform, but there was moderate central airway hyperdeposition (arrowheads). The outlined regions of interest were modified to avoid these areas. (b) Graph of clearance analysis data reveals accelerated 99mTc DTPA egress (half-time [T1/2], 27.9 minutes). The dotted line represents the clearance function fit to the first 8 minutes of data; the solid line represents the actual data. There was no chest radiograph obtained near the time the radioaerosol study was obtained.

View larger version (147K): [in a new window]   Figure 3a. (a) Posterior radioaerosol image obtained over the thorax at the end of the inhalation period. This group 1 10-year-old girl had a markedly abnormal chest radiograph (not shown) obtained 4 days before the 99mTc DTPA study. The radiograph depicted diffuse, bilateral, reticular areas of intense opacification and increased lung volume. The 99mTc DTPA deposition is markedly inhomogeneous, with numerous bilateral peripheral "hot spots." (b) Graph shows that the clearance half-time (T1/2) of 99mTc DTPA was rapid (20.6 minutes). The dotted line represents the clearance function fit to the first 8 minutes of data; the solid line represents the actual data. This patient had wasting syndrome and sepsis and died 10 months later.

View larger version (16K): [in a new window]   Figure 3b. (a) Posterior radioaerosol image obtained over the thorax at the end of the inhalation period. This group 1 10-year-old girl had a markedly abnormal chest radiograph (not shown) obtained 4 days before the 99mTc DTPA study. The radiograph depicted diffuse, bilateral, reticular areas of intense opacification and increased lung volume. The 99mTc DTPA deposition is markedly inhomogeneous, with numerous bilateral peripheral "hot spots." (b) Graph shows that the clearance half-time (T1/2) of 99mTc DTPA was rapid (20.6 minutes). The dotted line represents the clearance function fit to the first 8 minutes of data; the solid line represents the actual data. This patient had wasting syndrome and sepsis and died 10 months later.