Developing Asymmetric Breast Tissue1
Catherine W. Piccoli, MD,
Stephen A. Feig, MD and
Juan P. Palazzo, MD
1 From the Departments of Radiology (C.W.P., S.A.F.) and Pathology, Anatomy and Cell Biology (J.P.P.), Jefferson Medical College and Thomas Jefferson University Hospital, 132 S 10th St, 7th Fl, Main Bldg, Philadelphia, PA 19107. From the 1997 RSNA scientific assembly. Received April 16, 1998; revision requested June 24; revision received August 5; accepted October 6. Address reprint requests to C.W.P.
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Figure 2a. Enlarging benign asymmetric tissue. (a) Mediolateral oblique and (b) craniocaudal views at baseline mammography show benign-appearing amorphous tissue (arrow) in the upper outer part of the breast that was not present in the contralateral breast. (c) Mediolateral oblique and (d) craniocaudal views at mammography performed 5 years later show that this asymmetric tissue (arrow) has enlarged. (e) US scan reveals a band of hyperechoic tissue (arrows) that corresponds to the enlarging asymmetric tissue. An excisional biopsy specimen (not shown) of this tissue revealed extensive pseudoangiomatous stromal hyperplasia and ductal hyperplasia without atypia.
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Figure 2b. Enlarging benign asymmetric tissue. (a) Mediolateral oblique and (b) craniocaudal views at baseline mammography show benign-appearing amorphous tissue (arrow) in the upper outer part of the breast that was not present in the contralateral breast. (c) Mediolateral oblique and (d) craniocaudal views at mammography performed 5 years later show that this asymmetric tissue (arrow) has enlarged. (e) US scan reveals a band of hyperechoic tissue (arrows) that corresponds to the enlarging asymmetric tissue. An excisional biopsy specimen (not shown) of this tissue revealed extensive pseudoangiomatous stromal hyperplasia and ductal hyperplasia without atypia.
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Figure 2c. Enlarging benign asymmetric tissue. (a) Mediolateral oblique and (b) craniocaudal views at baseline mammography show benign-appearing amorphous tissue (arrow) in the upper outer part of the breast that was not present in the contralateral breast. (c) Mediolateral oblique and (d) craniocaudal views at mammography performed 5 years later show that this asymmetric tissue (arrow) has enlarged. (e) US scan reveals a band of hyperechoic tissue (arrows) that corresponds to the enlarging asymmetric tissue. An excisional biopsy specimen (not shown) of this tissue revealed extensive pseudoangiomatous stromal hyperplasia and ductal hyperplasia without atypia.
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Figure 2d. Enlarging benign asymmetric tissue. (a) Mediolateral oblique and (b) craniocaudal views at baseline mammography show benign-appearing amorphous tissue (arrow) in the upper outer part of the breast that was not present in the contralateral breast. (c) Mediolateral oblique and (d) craniocaudal views at mammography performed 5 years later show that this asymmetric tissue (arrow) has enlarged. (e) US scan reveals a band of hyperechoic tissue (arrows) that corresponds to the enlarging asymmetric tissue. An excisional biopsy specimen (not shown) of this tissue revealed extensive pseudoangiomatous stromal hyperplasia and ductal hyperplasia without atypia.
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Figure 2e. Enlarging benign asymmetric tissue. (a) Mediolateral oblique and (b) craniocaudal views at baseline mammography show benign-appearing amorphous tissue (arrow) in the upper outer part of the breast that was not present in the contralateral breast. (c) Mediolateral oblique and (d) craniocaudal views at mammography performed 5 years later show that this asymmetric tissue (arrow) has enlarged. (e) US scan reveals a band of hyperechoic tissue (arrows) that corresponds to the enlarging asymmetric tissue. An excisional biopsy specimen (not shown) of this tissue revealed extensive pseudoangiomatous stromal hyperplasia and ductal hyperplasia without atypia.
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Figure 3a. Developing benign asymmetric tissue. (a) Mediolateral view of the deep upper part of the breast on a baseline mammogram. (b) Mammogram of the same area as in a obtained 1 year later shows amorphous tissue (arrow) that was not present on the prior image. (c) Sagittal fat-suppressed, three-dimensional spoiled gradient-echo postcontrast MR image (26.9/3.1) shows no abnormal enhancement of this tissue (arrow). (d) Photomicrograph of an excisional biopsy specimen of this asymmetric tissue reveals ductal hyperplasia (straight arrows) and extensive pseudoangiomatous stromal hyperplasia (large area delineated by curved arrows). (Hematoxylin-eosin stain; original magnification, x150.)
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Figure 3b. Developing benign asymmetric tissue. (a) Mediolateral view of the deep upper part of the breast on a baseline mammogram. (b) Mammogram of the same area as in a obtained 1 year later shows amorphous tissue (arrow) that was not present on the prior image. (c) Sagittal fat-suppressed, three-dimensional spoiled gradient-echo postcontrast MR image (26.9/3.1) shows no abnormal enhancement of this tissue (arrow). (d) Photomicrograph of an excisional biopsy specimen of this asymmetric tissue reveals ductal hyperplasia (straight arrows) and extensive pseudoangiomatous stromal hyperplasia (large area delineated by curved arrows). (Hematoxylin-eosin stain; original magnification, x150.)
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Figure 3c. Developing benign asymmetric tissue. (a) Mediolateral view of the deep upper part of the breast on a baseline mammogram. (b) Mammogram of the same area as in a obtained 1 year later shows amorphous tissue (arrow) that was not present on the prior image. (c) Sagittal fat-suppressed, three-dimensional spoiled gradient-echo postcontrast MR image (26.9/3.1) shows no abnormal enhancement of this tissue (arrow). (d) Photomicrograph of an excisional biopsy specimen of this asymmetric tissue reveals ductal hyperplasia (straight arrows) and extensive pseudoangiomatous stromal hyperplasia (large area delineated by curved arrows). (Hematoxylin-eosin stain; original magnification, x150.)
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Figure 3d. Developing benign asymmetric tissue. (a) Mediolateral view of the deep upper part of the breast on a baseline mammogram. (b) Mammogram of the same area as in a obtained 1 year later shows amorphous tissue (arrow) that was not present on the prior image. (c) Sagittal fat-suppressed, three-dimensional spoiled gradient-echo postcontrast MR image (26.9/3.1) shows no abnormal enhancement of this tissue (arrow). (d) Photomicrograph of an excisional biopsy specimen of this asymmetric tissue reveals ductal hyperplasia (straight arrows) and extensive pseudoangiomatous stromal hyperplasia (large area delineated by curved arrows). (Hematoxylin-eosin stain; original magnification, x150.)
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Figure 4a. Gradually enlarging asymmetric tissue. Mediolateral views of the same breast (a) at baseline mammography, (b) at mammography 2 years later, (c) at mammography 6 years later, and (d) at mammography 9 years after baseline show the development and subsequent enlargement of benign-appearing asymmetric tissue (arrows in b–d) in the upper part of the breast. In a–c, the patient is premenopausal. The patient was asymptomatic and refused to undergo biopsy at the time the mammogram in b was obtained. (d) The postmenopausal mammogram shows a decrease in density of both the asymmetric tissue and the parenchymal tissue.
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Figure 4b. Gradually enlarging asymmetric tissue. Mediolateral views of the same breast (a) at baseline mammography, (b) at mammography 2 years later, (c) at mammography 6 years later, and (d) at mammography 9 years after baseline show the development and subsequent enlargement of benign-appearing asymmetric tissue (arrows in b–d) in the upper part of the breast. In a–c, the patient is premenopausal. The patient was asymptomatic and refused to undergo biopsy at the time the mammogram in b was obtained. (d) The postmenopausal mammogram shows a decrease in density of both the asymmetric tissue and the parenchymal tissue.
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Figure 4c. Gradually enlarging asymmetric tissue. Mediolateral views of the same breast (a) at baseline mammography, (b) at mammography 2 years later, (c) at mammography 6 years later, and (d) at mammography 9 years after baseline show the development and subsequent enlargement of benign-appearing asymmetric tissue (arrows in b–d) in the upper part of the breast. In a–c, the patient is premenopausal. The patient was asymptomatic and refused to undergo biopsy at the time the mammogram in b was obtained. (d) The postmenopausal mammogram shows a decrease in density of both the asymmetric tissue and the parenchymal tissue.
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Figure 4d. Gradually enlarging asymmetric tissue. Mediolateral views of the same breast (a) at baseline mammography, (b) at mammography 2 years later, (c) at mammography 6 years later, and (d) at mammography 9 years after baseline show the development and subsequent enlargement of benign-appearing asymmetric tissue (arrows in b–d) in the upper part of the breast. In a–c, the patient is premenopausal. The patient was asymptomatic and refused to undergo biopsy at the time the mammogram in b was obtained. (d) The postmenopausal mammogram shows a decrease in density of both the asymmetric tissue and the parenchymal tissue.
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Copyright © 1999 by the Radiological Society of North America.
= patients who underwent open excisional biopsy, x = patients who underwent core biopsy, 
= patients who were followed up mammographically. No measurements were taken after core or excisional biopsy was performed.