Fibrous Nodules Found at Large-Core Needle Biopsy of the Breast: Imaging Features1
Susan C. Harvey, MD,
Christine M. Denison, MD,
Susan C. Lester, MD, PhD,
Pamela J. DiPiro, MD,
Darrell N. Smith, MD and
Jack E. Meyer, MD
1 From the Departments of Radiology (S.C.H., C.M.D., P.J.D., D.N.S., J.E.M.) and Pathology (S.C.L.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115. Received March 25, 1998; revision requested June 15; revision received July 20; accepted October 19. Address reprint requests to S.C.H., Department of Radiology, University of Vermont College of Medicine, Fletcher Allen Health Care, University Health Center Campus, 1 S Prospect St, Burlington, VT 05401.
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Figure 1a. Mammographic and histologic findings of a fibrous nodule in a 41-year-old woman with low-suspicion imaging features. (a) Left craniocaudal mammogram demonstrates a 25 x 17-mm equal-density mass (arrows) with circumscribed margins. (b) Photomicrograph of a specimen demonstrates the surgically excised fibrous nodule. Note the margin of the nodule (arrow) adjacent to normal breast parenchyma. The lesion consists predominantly of interlobular stroma, and the epithelial elements are sparse and atrophic. (Hematoxylin-eosin stain; original magnification, x35.)
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Figure 1b. Mammographic and histologic findings of a fibrous nodule in a 41-year-old woman with low-suspicion imaging features. (a) Left craniocaudal mammogram demonstrates a 25 x 17-mm equal-density mass (arrows) with circumscribed margins. (b) Photomicrograph of a specimen demonstrates the surgically excised fibrous nodule. Note the margin of the nodule (arrow) adjacent to normal breast parenchyma. The lesion consists predominantly of interlobular stroma, and the epithelial elements are sparse and atrophic. (Hematoxylin-eosin stain; original magnification, x35.)
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Figure 2. Right mediolateral oblique mammogram in a 43-year-old woman shows an equal-density round mass (arrows) with indistinct margins in the upper part of the breast. Initial large-core needle biopsy and repeat surgical biopsy findings revealed a fibrous nodule.
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Figure 3a. Mammographic and histologic findings of a fibrous nodule in a 49-year-old woman with very suspicious imaging features. (a) Right craniocaudal mammogram shows a 1-cm mass (arrows) with spiculated margins in the posterior portion of the breast. (b) Photomicrograph of a specimen shows a fibrous nodule with an irregular margin that is clearly seen because of the surrounding adipose tissue. This configuration accounts for the spiculated mammographic appearance. This lesion consists almost exclusively of dense stroma, with minimal adipose tissue and nearly absent epithelial elements. A central area of hemorrhage (arrows) is the site of the initial large-core needle biopsy track. (Hematoxylin-eosin stain; original magnification, x35.)
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Figure 3b. Mammographic and histologic findings of a fibrous nodule in a 49-year-old woman with very suspicious imaging features. (a) Right craniocaudal mammogram shows a 1-cm mass (arrows) with spiculated margins in the posterior portion of the breast. (b) Photomicrograph of a specimen shows a fibrous nodule with an irregular margin that is clearly seen because of the surrounding adipose tissue. This configuration accounts for the spiculated mammographic appearance. This lesion consists almost exclusively of dense stroma, with minimal adipose tissue and nearly absent epithelial elements. A central area of hemorrhage (arrows) is the site of the initial large-core needle biopsy track. (Hematoxylin-eosin stain; original magnification, x35.)
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Figure 4. Sagittal US image in a 50-year-old woman with a fibrous nodule shows a hypoechoic, circumscribed mass (arrows), with slight posterior acoustic enhancement.
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Figure 5. Sagittal US image in a 36-year-old woman with a palpable, fibrous nodule shows a hypoechoic 11-mm mass (arrows) with irregular margins and posterior acoustic shadowing.
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Copyright © 1999 by the Radiological Society of North America.
