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Pulmonary MR Angiography with Ultrasmall Superparamagnetic Iron Oxide Particles as a Blood Pool Agent and a Navigator Echo for Respiratory Gating: Pilot Study¹

¹ From the Department of Radiology, Uppsala University, Sjukhusvgen 5-11 Akademiska Sjukhuset, 751 85 Uppsala, Sweden (K.H.A., L.O.J.); Philips Medical Systems, Best, the Netherlands (J.B.R.); the Department of Radiology, Örebro Medical Center Hospital, Örebro, Sweden (A.S.R.); and Nycomed Amersham Imaging, Oslo, Norway (P.A., A.B.). Received April 7, 1998; revision requested June 29; revision received September 8; accepted December 9. Supported in part by a grant from Nycomed Amersham Imaging. Address reprint requests to K.H.A.

View larger version (169K): [in a new window]   Figure 1a. Maximum intensity projection images of pulmonary MR angiograms obtained in one patient, with 4.0 mg Fe/kg NC100150 Injection. A = arterial branches, H = head, R = right, V = veins. (a) Partial image shows mainly arterial branches. Artifacts are seen as focal signal intensity decreases and increases along each vessel. Arrow = azygos arch, IVC = inferior vena cava. Overall image quality was judged very satisfactory. (b) Image shows almost the whole investigated volume. (c) Closest vessel view shows the whole investigated volume.

View larger version (148K): [in a new window]   Figure 1b. Maximum intensity projection images of pulmonary MR angiograms obtained in one patient, with 4.0 mg Fe/kg NC100150 Injection. A = arterial branches, H = head, R = right, V = veins. (a) Partial image shows mainly arterial branches. Artifacts are seen as focal signal intensity decreases and increases along each vessel. Arrow = azygos arch, IVC = inferior vena cava. Overall image quality was judged very satisfactory. (b) Image shows almost the whole investigated volume. (c) Closest vessel view shows the whole investigated volume.

View larger version (165K): [in a new window]   Figure 1c. Maximum intensity projection images of pulmonary MR angiograms obtained in one patient, with 4.0 mg Fe/kg NC100150 Injection. A = arterial branches, H = head, R = right, V = veins. (a) Partial image shows mainly arterial branches. Artifacts are seen as focal signal intensity decreases and increases along each vessel. Arrow = azygos arch, IVC = inferior vena cava. Overall image quality was judged very satisfactory. (b) Image shows almost the whole investigated volume. (c) Closest vessel view shows the whole investigated volume.

View larger version (179K): [in a new window]   Figure 2. Maximum intensity projection image of a pulmonary MR angiogram obtained with 2.5 mg Fe/kg NC100150 Injection. Overall image quality was judged unsatisfactory. The dotted line is an artifact from the patient monitoring equipment.

View larger version (192K): [in a new window]   Figure 3. Partial maximum intensity projection image of a pulmonary MR angiogram obtained with 1.0 mg Fe/kg NC100150 Injection. Overall image quality was judged very unsatisfactory. The dotted line is an artifact from the patient monitoring equipment.