Cystic Fibrosis: Combined Hyperpolarized 3He-enhanced and Conventional Proton MR Imaging in the Lung-Preliminary Observations1
Lane F. Donnelly, MD,
James R. MacFall, PhD,
H. Page McAdams, MD,
J. Marc Majure, MD,
Jean Smith, MS,
Donald P. Frush, MD,
Paul Bogonad, PhD,
H. Cecil Charles, PhD and
Carl E. Ravin, MD
1 From the Departments of Radiology, Division of Pediatric Radiology (L.F.D., J.R.M., H.P.M., J.S., D.P.F., P.B., H.C.C., C.E.R.) and Pediatrics, Division of Pulmonary Medicine (J.M.M.), Duke University Medical Center, Durham, NC. From the 1998 RSNA scientific assembly. Received September 17, 1998; revision requested November 10; revision received November 19; accepted March 29, 1999. Address reprint requests to L.F.D., Department of Radiology, Children's Hospital Medical Center and the University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH 45229-3039.
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Figure 1. Normal 3He MR image in a 53-year-old male volunteer. Coronal gradient-echo image (9.5/8 with 8° flip angle) through the posterior lung shows homogeneous high SI diffusely throughout the lungs. High SI from the hyperpolarized 3He is seen within the left main bronchus (arrow).
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Subject 2. Severe ventilation defects are disproportionately greater in distribution than are morphologic abnormalities in a 24-year-old woman with CF. (a) Coronal conventional fast SE MR image (3,000/80) at the level of the trachea shows areas of mildly increased linear and punctate nodular SI (arrowheads) within the upper and middle lung zones bilaterally, as well as bilateral hilar and subcarinal lymphadenopathy (arrows). (b) Coronal 3He gradient-echo MR image (9.5/8 with 8° flip angle) shows complete (right) and nearly complete (left) absence of SI within the upper lungs (arrows). There are also large areas of absent SI within the middle and lower lungs (arrowheads).
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Subject 2. Severe ventilation defects are disproportionately greater in distribution than are morphologic abnormalities in a 24-year-old woman with CF. (a) Coronal conventional fast SE MR image (3,000/80) at the level of the trachea shows areas of mildly increased linear and punctate nodular SI (arrowheads) within the upper and middle lung zones bilaterally, as well as bilateral hilar and subcarinal lymphadenopathy (arrows). (b) Coronal 3He gradient-echo MR image (9.5/8 with 8° flip angle) shows complete (right) and nearly complete (left) absence of SI within the upper lungs (arrows). There are also large areas of absent SI within the middle and lower lungs (arrowheads).
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Subject 1. Severe functional and morphologic abnormalities in a 20-year-old woman with CF. (a) Coronal conventional fast SE MR image (3,000/80) through the posterior lung shows bullous change (arrow) and increased linear and nodular SI (arrowheads) involving the upper and lower lobes bilaterally. (b) Coronal 3He gradient-echo MR image (9.5/8 with 8° flip angle) shows complete absence of SI in the upper lung bilaterally (arrows). There is also a large, wedge-shaped area of absent SI (arrowhead) within the lateral portion of the right middle lung.
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Subject 1. Severe functional and morphologic abnormalities in a 20-year-old woman with CF. (a) Coronal conventional fast SE MR image (3,000/80) through the posterior lung shows bullous change (arrow) and increased linear and nodular SI (arrowheads) involving the upper and lower lobes bilaterally. (b) Coronal 3He gradient-echo MR image (9.5/8 with 8° flip angle) shows complete absence of SI in the upper lung bilaterally (arrows). There is also a large, wedge-shaped area of absent SI (arrowhead) within the lateral portion of the right middle lung.
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Copyright © 1999 by the Radiological Society of North America.
