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Endovascular Creation of an in Vivo Bifurcation Aneurysm Model in Rabbits¹

¹ From the Departments of Radiology (H.J.C., T.A.A., W.F.M., R.J.R., M.E.J., J.E.D., D.F.K.), Neurosurgery (G.A.H., S.B.H.), and Pathology (J.W.M.), University of Virginia Health Sciences Center. Received April 13, 1998; revision requested July 1; final revision received December 16; accepted April 8, 1999. T.A.A. is supported by the RSNA Research and Education Foundation as a 1997 Research Resident. D.F.K. is supported by the RSNA Research and Education Foundation as a 1997 Bracco/RSNA Scholar. Address reprint requests to H.J.C., Department of Radiology, Emory University Hospital, 1364 Clifton Rd NE, Atlanta, GA 30322 (e-mail: harry_cloft@emory.org).

View larger version (173K): [in a new window]   Figure 1a. Left anterior oblique aortograms of the aortic arch demonstrate (a) a model aneurysm created without elastase infusion, which is completely thrombosed (arrow) after 1 month, and (b) a model aneurysm (arrows) created with elastase infusion, which is patent after 3 months and which has a size and bifurcation anatomy similar to that of human cerebral aneurysms.

View larger version (190K): [in a new window]   Figure 1b. Left anterior oblique aortograms of the aortic arch demonstrate (a) a model aneurysm created without elastase infusion, which is completely thrombosed (arrow) after 1 month, and (b) a model aneurysm (arrows) created with elastase infusion, which is patent after 3 months and which has a size and bifurcation anatomy similar to that of human cerebral aneurysms.

View larger version (122K): [in a new window]   Figure 2a. Photomicrographs of model aneurysms oriented along the plane of the aortic arch depict histologic findings. (a) Without the elastase infusion, the model is mostly thrombosed (short straight arrow) and is without aneurysm dilatation after 1 month. The balloon occlusion site is seen above the thrombus (long straight arrow). (b) With the elastase infusion, the model has some chronic thrombus formation in the dome (straight arrows) and is aneurysmally dilated after 1 month. (c) After 3 months, the model remains patent and aneurysmal. Chronic clot (straight arrows) in the dome is again noted. In a-c, the curved arrow indicates the superior wall of the aorta, and the bent arrow indicates the brachiocephalic trunk. (Hematoxylin-eosin stain; original magnification, x20.)

View larger version (141K): [in a new window]   Figure 2b. Photomicrographs of model aneurysms oriented along the plane of the aortic arch depict histologic findings. (a) Without the elastase infusion, the model is mostly thrombosed (short straight arrow) and is without aneurysm dilatation after 1 month. The balloon occlusion site is seen above the thrombus (long straight arrow). (b) With the elastase infusion, the model has some chronic thrombus formation in the dome (straight arrows) and is aneurysmally dilated after 1 month. (c) After 3 months, the model remains patent and aneurysmal. Chronic clot (straight arrows) in the dome is again noted. In a-c, the curved arrow indicates the superior wall of the aorta, and the bent arrow indicates the brachiocephalic trunk. (Hematoxylin-eosin stain; original magnification, x20.)

View larger version (138K): [in a new window]   Figure 2c. Photomicrographs of model aneurysms oriented along the plane of the aortic arch depict histologic findings. (a) Without the elastase infusion, the model is mostly thrombosed (short straight arrow) and is without aneurysm dilatation after 1 month. The balloon occlusion site is seen above the thrombus (long straight arrow). (b) With the elastase infusion, the model has some chronic thrombus formation in the dome (straight arrows) and is aneurysmally dilated after 1 month. (c) After 3 months, the model remains patent and aneurysmal. Chronic clot (straight arrows) in the dome is again noted. In a-c, the curved arrow indicates the superior wall of the aorta, and the bent arrow indicates the brachiocephalic trunk. (Hematoxylin-eosin stain; original magnification, x20.)

View larger version (141K): [in a new window]   Figure 3a. Photomicrographs of model aneurysms, obtained 1 month after creation of the aneurysms, are oriented along the plane of the aortic arch and depict histologic findings. (a) Without the elastase infusion, the elastic laminae (arrows) are intact. (b) With the elastase infusion, the elastic laminae persist (straight arrow) at the neck of the aneurysm but are destroyed (curved arrow) distally. (Verhoeff-van Giesen stain for elastin fibers; original magnification, x40.)

View larger version (118K): [in a new window]   Figure 3b. Photomicrographs of model aneurysms, obtained 1 month after creation of the aneurysms, are oriented along the plane of the aortic arch and depict histologic findings. (a) Without the elastase infusion, the elastic laminae (arrows) are intact. (b) With the elastase infusion, the elastic laminae persist (straight arrow) at the neck of the aneurysm but are destroyed (curved arrow) distally. (Verhoeff-van Giesen stain for elastin fibers; original magnification, x40.)