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Aortic Valve Replacement in Patients with Aortic Valve Stenosis Improves Myocardial Metabolism and Diastolic Function1

Hugo P. Beyerbacht, MD, Hildo J. Lamb, PhD, Arnoud van der Laarse, PhD, Hubert W. Vliegen, MD, Ferre Leujes, MSc, Marc G. Hazekamp, MD, Albert de Roos, MD and Ernst E. van der Wall, MD

1 From the Departments of Cardiology (H.P.B., A.v.d.L., H.W.V., F.L., E.E.v.d.W.), Radiology (H.J.L., A.d.R.), and Thoracic Surgery (M.G.H.), Leiden University Medical Center, Albinusdreef 2, 2333 2A Leiden, the Netherlands. Received March 13, 2000; revision requested May 14; revision received November 21; accepted December 11. Supported in part by the Stimuleringsfonds of the Dutch Heart Foundation the Netherlands Organization of Scientific Research grant #902-16-144. Address correspondence to H.J.L. (e-mail: h.j.lamb@lumc.nl).



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Figure 1. Line graphs of mitral valve flow are shown for a healthy control subject (solid line) and a patient before (dotted line) and after (dashed line) AVR. Typical early and atrial filling waves can be determined. Note the differences in peak heights and slopes between the graphs for the control subject and the patient.

 


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Figure 2. Sensitive volumes positioned in an optimal orientation relative to the LV on the basis of A, transverse and B, sagittal spin-echo scout MR images. By using two-dimensional image-selected in vivo spectroscopy and one-dimensional chemical shift imaging (spectroscopic imaging), the one-dimensional phase-encoding bar, with 32 rows of 1-cm thickness each, is angulated around the caudocranial body axis perpendicular to the chest wall. In this way, chest wall muscle is excluded from the first row containing myocardial tissue, row 25. B, By adjusting the level of the volume selection in the caudocranial direction, contamination of the sensitive volumes by diaphragm muscle and liver tissue is prevented. A and B, The white square on the chest wall originates from a sample in the center of the 10-cm-diameter surface coil. C, Resulting 31P MR spectra are shown separately for each row. On the basis of strict criteria previously published (6), cardiac spectra were identified and summed to provide one 31P MR spectrum. The PCr-ATP ratio and an estimate of the noise percentage are shown on the right for each spectrum.

 


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Figure 3. 31P MR spectra acquired from the LV anterior wall in a patient with severe aortic valve stenosis before (left) and after (right) AVR. Note the increase in the myocardial PCr-ATP ratio following AVR. Three separate peaks of ATP are indicated by {alpha}, ß, and {gamma}.

 


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Figure 4. Graph shows the myocardial PCr-ATP ratios of all 18 patients examined with MR spectroscopy before AVR and of the nine patients who underwent follow-up MR spectroscopy 40 weeks ± 12 after AVR. Ratios of the 10 control subjects are displayed as reference. Mean values (± SD) are indicated by symbols with error bars. Note the increases in the myocardial PCr-ATP ratio after AVR in seven of nine patients.

 





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