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Published online before print December 10, 2001, 10.1148/radiol.2222010570
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(Radiology 2002;222:468-473.)
© RSNA, 2002

Minimal Duration of Oral Matrix Metalloproteinase Inhibition to Prevent Constrictive Arterial Remodeling after Balloon Dilation in the Pig1

Marion J. Sierevogel, MD, Evelyn Velema, BSc, Peter P. de Jaegere, MD, PhD, Dominique P. de Kleijn, PhD, Cornelius Borst, MD, PhD and Gerard Pasterkamp, MD, PhD

1 From the Experimental Cardiology Laboratory, University Medical Center, Heidelberglaan 100, Room G02.523, Utrecht, the Netherlands. Received March 6, 2001; revision requested April 9; revision received June 1; accepted July 5. Supported by grant NHS 99.209 from the Dutch Heart Foundation. M.J.S. supported by the Sorbo Foundation. Address correspondence to G.P. (e-mail: g.pasterkamp@hli.azu.nl).



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  		Figure 1. Transverse intravascular US scans of the femoral artery in an untreated control and in a pig treated with BB-2516 after intervention (A, C) and at 42-day follow-up (B, D). The black circle represents the catheter (c). In B and D, the arrow represents the interface between the hypoechoic media and hyperechoic intima. The distance between the indicators is 1 mm. A, B, The untreated pig shows constrictive remodeling (smaller total follow-up VA of 13.8 mm2 compared with postintervention VA of 17.6 mm2). C, D, The artery of the pig treated with BB-2516 lacks constrictive remodeling (follow-up VA of 23.3 mm2 vs postintervention VA of 17.6 mm2).

 


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  		Figure 2. Bar graphs show late VA loss (top), late LA loss (middle), and intimal hyperplasia (bottom) at 42 days of follow-up for the control group (C) and the groups treated with BB-2516 for 2-42 days (d). A 69% reduction in late VA loss was achieved in the group treated with BB-2516 for 14 days compared with the control group. This inhibition of constrictive remodeling is consistent with a longer duration of BB-2516 treatment. Data are expressed as the mean ± SEM (represented by error bars). * = P value of .05 or less, groups treated with BB-2516 versus control group.

 




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