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Dementing Disorders: Volumetric Measurement of Cerebrospinal Fluid to Distinguish Normal from Pathologic Findings—Feasibility Study¹

¹ From the Division of Imaging Science and Biomedical Engineering, Medical School, University of Manchester, Oxford Rd, Manchester M13 9PT, England (N.A.T., S.S., A.J.); and Cognitive Function Unit, Central Manchester Healthcare Trust, Manchester, England (A.R.V., D.B., J.S.S., D.N.). Received February 5, 2001; revision requested March 26; revision received September 17; accepted January 7, 2002. Address correspondence to N.A.T. (e-mail: neil.thacker@man.ac.uk).

View larger version (183K): [in a new window]   Figure 1. Fast spin-echo inversion-recovery MR images depict positions of the boundary planes that define the 12 sample boxes (yellow lines) used for analysis. CSF MR images represent binarized volumes in the (top left) coronal, (top right) transverse, and (bottom) sagittal planes. The CSF volume has been rotated into the standard coordinate space, and the blue lines on the transverse and sagittal images show the position of the original baseline. The original baseline is not marked on the coronal image since no rotation from the acquisition geometry was required. S = superior, I = inferior, R = right, L = left, A = anterior, P = posterior.

View larger version (34K): [in a new window]   Figure 2a. (a) Plot of W2 (relative degree of atrophy between the central and anterior thirds of the coordinate space) versus W3 (overall level of atrophy) shows relatively tight clustering of data for the healthy elderly subjects (X) and the patients with VAD (). More extensive atrophy is seen in patients with AD () and FTD (+). Also note the separate distribution of patients with FTD or AD, which indicates distinct patterns of atrophy in each disease. (b) Plot of W1 (relative degree of atrophy between the anterior and central thirds of the coordinate space) versus W4 (left-right asymmetry). Note the presence of asymmetry in many patients with AD () or FTD (+); the degree of asymmetry is greater in patients with FTD and is biased to the left side (negative values of W4). = patients with VAD.

View larger version (33K): [in a new window]   Figure 2b. (a) Plot of W2 (relative degree of atrophy between the central and anterior thirds of the coordinate space) versus W3 (overall level of atrophy) shows relatively tight clustering of data for the healthy elderly subjects (X) and the patients with VAD (). More extensive atrophy is seen in patients with AD () and FTD (+). Also note the separate distribution of patients with FTD or AD, which indicates distinct patterns of atrophy in each disease. (b) Plot of W1 (relative degree of atrophy between the anterior and central thirds of the coordinate space) versus W4 (left-right asymmetry). Note the presence of asymmetry in many patients with AD () or FTD (+); the degree of asymmetry is greater in patients with FTD and is biased to the left side (negative values of W4). = patients with VAD.