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DOI: 10.1148/radiol.2253020060
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Pitfalls when Drawing Conclusions from in Vitro Experiments with High Concentrations of Radiographic Contrast Agents1

Tore Skotland, PhD

1 From the Department of Research and Development, Amersham Health, Nycoveien 2, N-0401 Oslo, Norway. Received February 14, 2002; revision requested March 13; revision received April 29; accepted May 24. Address correspondence to the author (e-mail: tore.skotland@amersham.com).



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Depiction of the high concentration of molecules in radiographic contrast media solutions. The two boxes represent a 1.2-nm-deep 12 x 12-nm section of the solution; that is, the small squares are 1.2 x 1.2 nm, and each solid circle represents a single contrast agent molecule of iohexol with dimensions of 1.0 x 1.2 x 1.2 nm. Upper box represents 150 mg of iodine per milliliter of iohexol, which is equivalent to approximately 0.4 mol/L solution. Lower box represents 75 mg of iodine per milliliter of iohexol, which is equivalent to approximately 0.2 mol/L solution; in this box, the size of one globular enzyme molecule (cross-hatched circle) of size similar to that of albumin is also shown.

 





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