Published online before print May 15, 2003, 10.1148/radiol.2281011963
Influence of Irradiated Volume on Ureteral Injury after Intraoperative Radiation Therapy: Experimental Study in Dogs1
Michael van Kampen, MD,
Michael J. Eble, MD,
Robert Krempien, MD,
Katrin Jensen, PhD,
Barbar Aydenitz, MD,
Martin Metzger, PhD,
Frank Hensley, PhD,
Sabine Haufe, MD,
Folker Amelung, MD,
Diethelm Wallwiener, MD and
Michael Wannenmacher, MD, DDS
1 From the Department of Radiation Oncology, Krankenhaus Nordwest, Steinbacher Hohl 2-26, D-60244 Frankfurt, Germany (M.v.K.); Department of Radiation Oncology, University of Aachen, Germany (M.J.E.); Department of Radiation Oncology (R.K., M.M., F.H., M.W.), Institute of Medical Biometry and Informatics (K.J.), and Department of Nuclear Medicine (S.H.), University of Heidelberg, Germany; Department of Gynecology, University of Tübingen, Germany (B.A., D.W.); and German Cancer Research Center, Heidelberg, Germany (F.A.). From the 2001 RSNA scientific assembly. Received November 30, 2001; revision requested February 13, 2002; final revision received October 21; accepted November 27. Supported by a grant from the Forschungskommission der medizinischen Fakultät der Universität Heidelberg. Address correspondence to M.v.K. (e-mail: m.van_kampen@khnw.de).
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Figure 1. Diagram of the experimental design. IORT = intraoperative radiation therapy.
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Figure 2. Bar graph shows MR imaging findings: progression of the small-volume group. Vertical axis is number of animals. Gray bars indicate the number of animals without ureteral obstruction. IORT = intraoperative radiation therapy.
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Figure 3. Bar graph shows MR imaging findings: progression of the medium-volume group. Vertical axis is number of animals. Gray bars indicate the number of animals without ureteral obstruction, and black bars indicate the number of animals with ureteral obstruction. IORT = intraoperative radiation therapy.
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Figure 4. Bar graph shows MR imaging findings: progression of the large-volume group. Vertical axis is number of animals. Gray bars indicate the number of animals without ureteral obstruction, and black bars indicate the number of animals with ureteral obstruction. IORT = intraoperative radiation therapy.
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Figure 5. Graph shows resting sequential renographic findings 6 months after irradiation: number of animals and degree of ureteral injury. Vertical axis is number of animals. White bars indicate the number of animals without ureteral obstruction, gray bars indicate the number of animals with intermediate excretion disturbance, and black bars indicate the number of animals with ureteral obstruction.
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Figure 6. Graph shows resting sequential renographic findings 12 months after irradiation: number of animals and degree of ureteral injury. Vertical axis is number of animals. White bars indicate the number of animals without ureteral obstruction, gray bars indicate the number of animals with intermediate excretion disturbance, and black bars indicate the number of animals with ureteral obstruction.
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Figure 7. Number of animals with (black bars) and number without (gray bars) ureteral injury at MR imaging and sequential renography 12 months after irradiation. Vertical axis is number of animals. The progression of the number of animals with ureteral injury independence from the irradiated volume is statistically significant (P = .034, Cochran-Armitage test).
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Copyright © 2003 by the Radiological Society of North America.
