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Coronary Arteries: Contrast-enhanced MR Imaging with SH L 643A—Experience in 12 Volunteers¹

¹ From the Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany (C.U.H., J.B., P.H.); German Heart Institute, Berlin, Germany (I.P., E.N.); Schering, Berlin, Germany (M.M.); and Berlex, Montville, NJ (K.S.). Received August 20, 2002; revision requested October 21; revision received November 18; accepted January 27, 2003. Address correspondence to J.B. (e-mail: joerg.barkhausen@uni-essen.de).

View larger version (72K): [in a new window]   Figure 1. Breath-hold 3D coronary MR angiograms (oblique inversion-recovery breath-hold T1-weighted gradient-recalled-echo fast low-angle shot). A, On nonenhanced image, the left coronary system (arrow) is poorly seen. B, On contrast-enhanced image, the left main and left anterior descending arteries (arrow) can be nicely delineated 2 minutes after intravenous injection of SH L 643A as a result of considerable increase in blood-to-myocardium CNR.

View larger version (104K): [in a new window]   Figure 2. A, Maximum intensity projection from breath-hold 3D coronary MR angiography (oblique inversion-recovery breath-hold T1-weighted gradient-recalled-echo fast low-angle shot) of the right coronary artery system in a 28-year-old volunteer. B, Maximum intensity projection from respiratory-gated coronary MR angiography (oblique inversion-recovery navigator-gated and motion-corrected segmented k-space T1-weighted gradient-echo) of the corresponding anatomic region in a 27-year-old volunteer. Both imaging techniques nicely display the right coronary artery (straight arrow) and proximal parts of the left main coronary artery (curved arrow).

View larger version (17K): [in a new window]   Figure 3. Bar graph represents the increase and time course of the blood-to-myocardium CNR following administration of SH L 643A, as acquired in six volunteers with breath-hold coronary MR angiography. Because of shorter image acquisition times compared with those of free-breathing respiratory-gated techniques, this method permits repetitive examinations. Peak CNR is reached as soon as 1-3 minutes after administration of the compound. Error bars = standard errors, * = P < .01 compared with nonenhanced (pre) imaging.

View larger version (17K): [in a new window]   Figure 4. Bar graph represents the increase and time course of the signal intensity (SI) of blood (black bars) and myocardium (gray bars) following administration of SH L 643A, as acquired in six volunteers with breath-hold coronary MR angiography. Peak CNR is reached as soon as 1-3 minutes after administration of the compound. Error bars = mean standard errors.